Full Product Name
BAPX1 Antibody
Product Synonym Names
Homeobox protein Nkx-3.2, NKH3-2, NKX3B, SMMD
Product Gene Name
anti-BAPX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Specificity
BAPX1 antibody is predicted not to cross-react with other NKX homeobox proteins.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Immunogen Description
Raised against a 19 amino acid peptide near the center of human BAPX1.
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-BAPX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BAPX1 antibody
BAPX1 is the mammalian homolog of the Drosophila bagpipe homeobox gene and is expressed in the splanchnic mesoderm and embryonic skeleton. It is one of the earliest developmental markers for the sclerotome portion of the somite and the gut mesentery. BAPX1 is required for normal skeletal development; homozygous inactivating mutations in the BAPX1 gene result in spodylo-megaepiphyseal-metaphyseal dysplasia (SMMD). It has also been suggested to play a role in the proper development of the mammalian gut and is required for distal stomach development as part of a BARX1-dependent pathway.
Product Categories/Family for anti-BAPX1 antibody
Total protein Ab
Applications Tested/Suitable for anti-BAPX1 antibody
ELISA (EIA), Western Blot (WB)
Western Blot (WB) of anti-BAPX1 antibody
Western blot analysis of BAPX1 in human brain tissue lysate with BAPX1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
NCBI/Uniprot data below describe general gene information for BAPX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001180
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NCBI GenBank Nucleotide #
NM_001189.3
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UniProt Secondary Accession #
Q2M2I7[Other Products]
UniProt Related Accession #
P78367[Other Products]
Molecular Weight
34,814 Da
NCBI Official Full Name
homeobox protein Nkx-3.2
NCBI Official Synonym Full Names
NK3 homeobox 2
NCBI Official Symbol
NKX3-2??[Similar Products]
NCBI Official Synonym Symbols
SMMD; BAPX1; NKX3B; NKX3.2
??[Similar Products]
NCBI Protein Information
homeobox protein Nkx-3.2
UniProt Protein Name
Homeobox protein Nkx-3.2
UniProt Synonym Protein Names
Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B
UniProt Gene Name
NKX3-2??[Similar Products]
UniProt Synonym Gene Names
BAPX1; NKX3B??[Similar Products]
UniProt Entry Name
NKX32_HUMAN
NCBI Summary for BAPX1
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
UniProt Comments for BAPX1
NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.
Protein type: Transcription factor; DNA-binding; Cell development/differentiation
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleus
Biological Process: spleen development; transcription from RNA polymerase II promoter; organ formation; skeletal morphogenesis; embryonic skeletal development; pancreas development; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; determination of left/right symmetry; skeletal development; negative regulation of apoptosis
Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia
Research Articles on BAPX1
1. Ihh-induced Nkx3.2 degradation requires Wnt5a, which is capable of triggering Nkx3.2 degradation
Precautions
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Disclaimer
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