Homeobox protein Nkx-3.2; Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of NKX3-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus.

Epigenetics and Nuclear Signaling/Epigenetics and Nuclear Signaling /Epigenetics and Nuclear Signaling

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

34,814 Da

NK3 homeobox 2

homeobox protein Nkx-3.2; homeobox protein NK-3 homolog B; bagpipe homeobox protein homolog 1

Homeobox protein Nkx-3.2

BAPX1; NKX3B??[Similar Products]

NKX32_HUMAN

This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]

NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.

Protein type: Transcription factor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleus

Biological Process: spleen development; transcription from RNA polymerase II promoter; organ formation; skeletal morphogenesis; embryonic skeletal development; pancreas development; negative regulation of chondrocyte differentiation; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; skeletal development; negative regulation of apoptosis

Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia

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