Cardiac inward rectifier; CIR; G protein-activated inward rectifier potassium channel 4; Heart KATP channel; Inward rectifier K channel Kir3.4; IRK5; KATP-1; KCNJ5; Kir3.4; Potassium channel, inwardly rectifying, subfamily J, member 5

For Research Use Only. Not for use in diagnostic procedures.

KCNJ5 antibody detects endogenous levels of total KCNJ5 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-KCNJ5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:5000

Peptide-+ Western blot analysis of extracts from HeLa cells, using KCNJ5 antibody. Immunofluorescence analysis of A549 cells, using KCNJ5 antibody.

47,668 Da

potassium voltage-gated channel subfamily J member 5

G protein-activated inward rectifier potassium channel 4

G protein-activated inward rectifier potassium channel 4

GIRK4; GIRK-4; CIR; IRK-4??[Similar Products]

This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.

Ashford M.L.J., Nature 370:456-459(1994). Ashford M.L.J., Nature 378:792-792(1995). Schoots O., Cell. Signal. 11:871-883(1999).

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