Product Name
Mesothelin (Msln), Recombinant Protein
Popular Item
Full Product Name
Recombinant Mouse Mesothelin
Product Synonym Names
Pre-pro-megakaryocyte-potentiating factor
Product Gene Name
Msln recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
298-600aa; Partial
Sequence
DAEQKACPPG KEPYKVDEDL IFYQNWELEA CVDGTMLARQ MDLVNEIPFT YEQLSIFKHK LDKTYPQGYP ESLIQQLGHF FRYVSPEDIH QWNVTSPDTV KTLLKVSKGQ KMNAQAIALV ACYLRGGGQL DEDMVKALGD IPLSYLCDFS PQDLHSVPSS VMWLVGPQDL DKCSQRHLGL LYQKACSAFQ NVSGLEYFEK IKTFLGGASV KDLRALSQHN VSMDIATFKR LQVDSLVGLS VAEVQKLLGP NIVDLKTEED KSPVRDWLFR QHQKDLDRLG LGLQGGIPNG YLVLDFNVRE AFS
3D Structure
ModBase 3D Structure for Q61468
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Msln recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Msln recombinant protein
membrane-anchored forms may play a role in cellular adhesion.
SDS-Page of Msln recombinant protein
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Msln. It may not necessarily be applicable to this product.
NCBI Accession #
NP_061345.1
[Other Products]
NCBI GenBank Nucleotide #
NM_018857.1
[Other Products]
UniProt Primary Accession #
Q61468
[Other Products]
UniProt Related Accession #
Q61468[Other Products]
NCBI Official Full Name
mesothelin
NCBI Official Synonym Full Names
mesothelin
NCBI Official Symbol
Msln??[Similar Products]
NCBI Official Synonym Symbols
MPF
??[Similar Products]
NCBI Protein Information
mesothelin
UniProt Protein Name
Mesothelin
UniProt Synonym Protein Names
Pre-pro-megakaryocyte-potentiating factor
Protein Family
Mesothelin
UniProt Gene Name
Msln??[Similar Products]
UniProt Synonym Gene Names
Mes; Mpf; MPF??[Similar Products]
UniProt Entry Name
MSLN_MOUSE
UniProt Comments for Msln
MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, GPI anchor
Cellular Component: cell surface; extracellular region; extracellular space; Golgi apparatus; membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell adhesion; cell-matrix adhesion
Product References and Citations for Msln recombinant protein
Mouse megakaryocyte potentiating factor cDNA.Kojima T., Taniguchi Y., Hattori K., Oh-eda M.
Mesothelin is not required for normal mouse development or reproduction.Bera T.K., Pastan I.Mol. Cell. Biol. 20:2902-2906(2000)
Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells.Prieve M.G., Moon R.T.BMC Dev. Biol. 3:2-2(2003)
Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion.Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.J. Biol. Chem. 279:9190-9198(2004)
Research Articles on Msln
1. MSLN has an important role in the growth of lung cancer cells in vivo raising the possibility that inactivation of MPF may be a useful treatment for lung and other MSLN expressing cancers.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
