Product Name
Mesothelin (MSLN), Polyclonal Antibody
Full Product Name
Rabbit anti-human Mesothelin polyclonal Antibody, FITC
Product Synonym Names
CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor; MPF
Product Gene Name
anti-MSLN antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13421
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant human Mesothelin protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27714 / sc-27700 / sc-27701 / sc-50426
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MSLN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MSLN antibody
Membrane-anchored forms may play a role in cellular adhesion.Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Applications Tested/Suitable for anti-MSLN antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MSLN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001170826.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001177355.1
[Other Products]
UniProt Primary Accession #
Q13421
[Other Products]
UniProt Secondary Accession #
Q14859; Q4VQD5; Q96GR6; Q96KJ5; Q9BR17; Q9BTR2; Q9UCB2; Q9UK57; D3DU65[Other Products]
UniProt Related Accession #
Q13421[Other Products]
Molecular Weight
67,940 Da
NCBI Official Full Name
mesothelin isoform 1 preproprotein
NCBI Official Synonym Full Names
mesothelin
NCBI Official Symbol
MSLN??[Similar Products]
NCBI Official Synonym Symbols
MPF; SMRP
??[Similar Products]
NCBI Protein Information
mesothelin
UniProt Protein Name
Mesothelin
UniProt Synonym Protein Names
CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor
Protein Family
Mesothelin
UniProt Gene Name
MSLN??[Similar Products]
UniProt Synonym Gene Names
MPF; MPF??[Similar Products]
UniProt Entry Name
MSLN_HUMAN
NCBI Summary for MSLN
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
UniProt Comments for MSLN
MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cell surface; extracellular space; Golgi apparatus; membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell adhesion; cell-matrix adhesion; pancreas development
Research Articles on MSLN
1. Expression of mesothelin was observed in 42.3% of patients with triple negative breast cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
