Product Name
Mesothelin (Msln), Polyclonal Antibody
Full Product Name
Anti-Mesothelin Rabbit pAb
Product Synonym Names
CAK1; Mesothelin; MPF; SMR; SMRP
Product Gene Name
anti-Msln antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13421
Specificity
Mesothelin Antibody detects endogenous levels of total Mesothelin
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human Mesothelin
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-Msln antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Msln antibody
Membrane-anchored forms may play a role in cellular adhesion.
Applications Tested/Suitable for anti-Msln antibody
Western Blot (WB), Immunhistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-Msln antibody
WB: 1:500-1:2000
IHC: 1:100-1:500
IP: 1:50
Western Blot (WB) of anti-Msln antibody
Western blot analysis of Mesothelin expression in HeLa cell lysate.
NCBI/Uniprot data below describe general gene information for Msln. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001170826.1
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NCBI GenBank Nucleotide #
NM_001177355.2
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UniProt Primary Accession #
Q13421
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UniProt Secondary Accession #
Q14859; Q4VQD5; Q96GR6; Q96KJ5; Q9BR17; Q9BTR2; Q9UCB2; Q9UK57; D3DU65[Other Products]
UniProt Related Accession #
Q13421[Other Products]
Molecular Weight
69; 40kDa
NCBI Official Full Name
mesothelin isoform 1 preproprotein
NCBI Official Synonym Full Names
mesothelin
NCBI Official Symbol
MSLN??[Similar Products]
NCBI Official Synonym Symbols
MPF; SMRP
??[Similar Products]
NCBI Protein Information
mesothelin
UniProt Protein Name
Mesothelin
UniProt Synonym Protein Names
CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor
Protein Family
Mesothelin
UniProt Gene Name
MSLN??[Similar Products]
UniProt Synonym Gene Names
MPF; MPF??[Similar Products]
NCBI Summary for Msln
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Comments for Msln
Membrane-anchored forms may play a role in cellular adhesion.
Research Articles on Msln
1. Our goal was to stimulate antitumor immunity by combining SS1P or LMB-100 with anti-CTLA-4. We constructed a BALB/c breast cancer cell line expressing human mesothelin (66C14-M), which was implanted in one or two locations. SS1P or LMB-100 was injected directly into established tumors and anti-CTLA-4 administered i.p. In mice with two tumors, one tumor was injected with immunotoxin and the other was not.
Precautions
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Disclaimer
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