Full Product Name
Rabbit DNL4 Antibody
Product Gene Name
anti-DNL4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 13; NC_000013.10 (108859790..108870716, complement). Location: 13q33-q34
3D Structure
ModBase 3D Structure for P49917
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-DNL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DNL4 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DNL4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001091738.1
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NCBI GenBank Nucleotide #
NM_001098268.1
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UniProt Primary Accession #
P49917
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UniProt Secondary Accession #
Q8IY66; Q8TEU5[Other Products]
UniProt Related Accession #
P49917[Other Products]
Molecular Weight
103,971 Da
NCBI Official Full Name
DNA ligase 4
NCBI Official Synonym Full Names
ligase IV, DNA, ATP-dependent
NCBI Official Symbol
LIG4??[Similar Products]
NCBI Protein Information
DNA ligase 4; sealase; DNA joinase; DNA ligase IV; DNA repair enzyme; polynucleotide ligase; polydeoxyribonucleotide synthase [ATP] 4
UniProt Protein Name
DNA ligase 4
UniProt Synonym Protein Names
DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4
UniProt Gene Name
LIG4??[Similar Products]
UniProt Entry Name
DNLI4_HUMAN
NCBI Summary for DNL4
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for DNL4
LIG4: a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. Defects in this gene are the cause of LIG4 syndrome.
Protein type: EC 6.5.1.1; Ligase
Chromosomal Location of Human Ortholog: 13q33-q34
Cellular Component: nucleoplasm; DNA ligase IV complex; focal adhesion; cytoplasm; plasma membrane; condensed chromosome; DNA-dependent protein kinase complex; nucleus
Molecular Function: protein C-terminus binding; protein binding; DNA binding; DNA ligase activity; metal ion binding; DNA ligase (ATP) activity; ATP binding; ligase activity
Biological Process: central nervous system development; viral reproduction; somatic stem cell maintenance; T cell differentiation in the thymus; chromosome organization and biogenesis; double-strand break repair via nonhomologous end joining; DNA ligation; positive regulation of fibroblast proliferation; double-strand break repair; DNA ligation during DNA repair; response to gamma radiation; negative regulation of neuron apoptosis; DNA ligation during DNA recombination; response to X-ray; pro-B cell differentiation; single strand break repair; positive regulation of neurogenesis; V(D)J recombination; immunoglobulin V(D)J recombination; in utero embryonic development; isotype switching; cell cycle; DNA repair; lagging strand elongation; cell proliferation; neuron apoptosis; cell division; T cell receptor V(D)J recombination; nucleotide-excision repair, DNA gap filling
Disease: Myeloma, Multiple; Lig4 Syndrome
Research Articles on DNL4
1. C, rs1805389 C>T, rs1805388 C>T and rs2232641 A>G) and breast cancer risk.">No association between LIG4 gene polymorphisms (rs1805386 T>C, rs1805389 C>T, rs1805388 C>T and rs2232641 A>G) and breast cancer risk.
Precautions
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Disclaimer
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