Human Homeobox protein Nkx-3.2 (NKX3-2) ELISA kit; BAPX1; MGC138171; NKX3.2; NKX3B; bagpipe homeobox 1; bagpipe homeobox homolog 1; NK3 homeobox 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NKX3-2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9318442 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NK3 homeobox 2 (NKX3-2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NKX3-2. The ELISA analytical biochemical technique of the MBS9318442 kit is based on NKX3-2 antibody-NKX3-2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NKX3-2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NKX3-2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

34,814 Da

NK3 homeobox 2

homeobox protein Nkx-3.2; homeobox protein NK-3 homolog B; bagpipe homeobox protein homolog 1

Homeobox protein Nkx-3.2

BAPX1; NKX3B??[Similar Products]

NKX32_HUMAN

This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]

NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.

Protein type: Transcription factor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleus

Biological Process: spleen development; transcription from RNA polymerase II promoter; organ formation; skeletal morphogenesis; embryonic skeletal development; pancreas development; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; determination of left/right symmetry; skeletal development; negative regulation of apoptosis

Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia

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