Full Product Name
KCNJ5 Antibody, Biotin conjugated
Product Synonym Names
G protein-activated inward rectifier potassium channel 4; GIRK-4; Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; Potassium channel; inwardly rectifying subfamily J member 5; KCNJ5; GIRK4
Product Gene Name
anti-KCNJ5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48544
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human G protein-activated inward rectifier potassium channel 4 protein (348-419AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-KCNJ5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNJ5 antibody
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Product Categories/Family for anti-KCNJ5 antibody
Neuroscience; Cancer; Cardiovascular; Metabolism; Signal transduction
Applications Tested/Suitable for anti-KCNJ5 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for KCNJ5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000881.3
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NCBI GenBank Nucleotide #
NM_000890.4
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UniProt Primary Accession #
P48544
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UniProt Secondary Accession #
Q6DK13; Q6DK14; Q92807; B2R744[Other Products]
UniProt Related Accession #
P48544[Other Products]
Molecular Weight
47,668 Da
NCBI Official Full Name
G protein-activated inward rectifier potassium channel 4
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 5
NCBI Official Symbol
KCNJ5??[Similar Products]
NCBI Official Synonym Symbols
CIR; GIRK4; KATP1; LQT13; KIR3.4
??[Similar Products]
NCBI Protein Information
G protein-activated inward rectifier potassium channel 4
UniProt Protein Name
G protein-activated inward rectifier potassium channel 4
UniProt Synonym Protein Names
Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5
Protein Family
G protein-activated inward rectifier potassium channel
UniProt Gene Name
KCNJ5??[Similar Products]
UniProt Synonym Gene Names
GIRK4; GIRK-4; CIR; IRK-4??[Similar Products]
NCBI Summary for KCNJ5
This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017]
UniProt Comments for KCNJ5
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.
Research Articles on KCNJ5
1. An aldosterone-driving KCNJ5 mutation was detected in juvenile primary aldosteronism, but not in the histologically normal cortex.
Precautions
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Disclaimer
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