Mouse Disrupted in schizophrenia 1 protein (DISC1) ELISA kit; RP4-730B13.1; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; SCZD9; ; disrupted in schizophrenia 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of DISC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9342658 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the disrupted in schizophrenia 1 (DISC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DISC1. The ELISA analytical biochemical technique of the MBS9342658 kit is based on DISC1 antibody-DISC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DISC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DISC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

92,525 Da

disrupted in schizophrenia 1

disrupted in schizophrenia 1 homolog

Disrupted in schizophrenia 1 homolog

DISC1_MOUSE

DISC1: Involved in the regulation of multiple aspects of embryonic and ***** neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the ***** dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during ***** neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1. Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell development/differentiation

Cellular Component: microtubule; centrosome; mitochondrion; endoplasmic reticulum; dynein complex; postsynaptic membrane; kinesin complex; cytoskeleton; membrane; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; synapse; nucleus; cell junction

Molecular Function: protein binding; kinesin binding; protein complex binding

Biological Process: nervous system development; positive regulation of neuroblast proliferation; mitochondrial calcium ion homeostasis; Wnt receptor signaling pathway; TOR signaling pathway; cell proliferation in forebrain; pyramidal neuron migration; multicellular organismal development; positive regulation of axon extension; neuron migration; Wnt receptor signaling pathway through beta-catenin; microtubule cytoskeleton organization and biogenesis; protein localization; cilium biogenesis; cerebral cortex radially oriented cell migration; positive regulation of cell-matrix adhesion; positive regulation of Wnt receptor signaling pathway

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