Homeobox protein Nkx-32; Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B; NKX3-2; BAPX1; NKX3B

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This NKX3-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-235 amino acids from the Central region of human NKX3-2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-NKX3-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the NK family of
homeobox-containing proteins. The encoded protein may play a role
in skeletal development.

Crown Antibodies

Western Blot (WB), ELISA (EIA)

WB~~1:1000

NKX3-2 Antibody (Center) western blot analysis in U266 cell line lysates (35ug/lane).This demonstrates the NKX3-2 antibody detected the NKX3-2 protein (arrow).

34814

NK3 homeobox 2

homeobox protein Nkx-3.2

Homeobox protein Nkx-3.2

BAPX1; NKX3B??[Similar Products]

NKX32_HUMAN

This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]

NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.

Protein type: DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleus

Biological Process: spleen development; transcription from RNA polymerase II promoter; organ formation; skeletal morphogenesis; embryonic skeletal development; negative regulation of chondrocyte differentiation; pancreas development; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; skeletal development; negative regulation of apoptosis

Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia

Hellemans, J., et al. Am. J. Hum. Genet. 85(6):916-922(2009)
Rodrigo, I., et al. Mol. Cell. Biol. 24(7):2757-2766(2004)
Tribioli, C., et al. Gene 203(2):225-233(1997)
Yoshiura, K.I., et al. Genomics 45(2):425-428(1997)
Tribioli, C., et al. Mech. Dev. 65 (1-2), 145-162 (1997) :

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