Full Product Name
CCBE1 (KIAA1983, Collagen and Calcium-binding EGF Domain-containing Protein 1, Full of Fluid Protein Homolog, FLJ30681, MGC50861, UNQ1921/PRO4395)
Product Synonym Names
Anti -CCBE1 (KIAA1983, Collagen and Calcium-binding EGF Domain-containing Protein 1, Full of Fluid Protein Homolog, FLJ30681, MGC50861, UNQ1921/PRO4395)
Product Gene Name
anti-CCBE1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MVKAGTCCAT CKEFYQMKQT VLQLKQKIAL LPNNAADLGK YITGDKVLAS NTYLPGPPGL PGGQGPPGSP GPKGSPGFPG MPGPPGQPGP RGSMGPMGPS PDLSHIKQGR RGPVGPPGAP GRDGSKGERG APGPRGSPGP PGSFDFLLLM LADIRNDITE LQEKVFGHRT HSSAEEFPLP QEFPSYPEAM DLGSGDDHPR RTETRDLRAP RDFYP
Chromosome Location
Chromosome: 18; NC_000018.9 (57098171..57364860, complement). Location: 18q21.32
3D Structure
ModBase 3D Structure for Q6UXH8
Specificity
Recognizes human CCBE1.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human CCBE1, aa1-215 (AAH46645.1).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CCBE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CCBE1 antibody
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans.
Product Categories/Family for anti-CCBE1 antibody
Antibodies; Abs to Calcium Binding Proteins
Applications Tested/Suitable for anti-CCBE1 antibody
Western Blot (WB)
Application Notes for anti-CCBE1 antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for CCBE1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_597716.1
[Other Products]
NCBI GenBank Nucleotide #
NM_133459.3
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UniProt Primary Accession #
Q6UXH8
[Other Products]
UniProt Secondary Accession #
Q6MZX5; Q86SS2; Q8TF19[Other Products]
UniProt Related Accession #
Q6UXH8[Other Products]
Molecular Weight
44,103 Da[Similar Products]
NCBI Official Full Name
collagen and calcium-binding EGF domain-containing protein 1
NCBI Official Synonym Full Names
collagen and calcium binding EGF domains 1
NCBI Official Symbol
CCBE1??[Similar Products]
NCBI Protein Information
collagen and calcium-binding EGF domain-containing protein 1; full of fluid protein homolog
UniProt Protein Name
Collagen and calcium-binding EGF domain-containing protein 1
UniProt Synonym Protein Names
Full of fluid protein homolog
Protein Family
Collagen and calcium-binding EGF domain-containing protein
UniProt Gene Name
CCBE1??[Similar Products]
UniProt Synonym Gene Names
KIAA1983??[Similar Products]
UniProt Entry Name
CCBE1_HUMAN
NCBI Summary for CCBE1
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans. [provided by RefSeq, Mar 2010]
UniProt Comments for CCBE1
Function: Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Ref.6
Subcellular location: Secreted
Potential.
Tissue specificity: Not expressed in blood or lymphatic endothelial cells. Ref.5
Involvement in disease: Hennekam lymphangiectasia-lymphedema syndrome (HLLS) [MIM:235510]: A generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7
Sequence similarities: Belongs to the CCBE1 family.Contains 2 collagen-like domains.Contains 1 EGF-like domain.
Sequence caution: The sequence BAB85569.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on CCBE1
1. The study has shown that CCBE1 mutations are not a major contributor to non-immune hydrops fetalis.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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