Aminopeptidase O; AP-O; 3411-; AOPEP; C9orf3; ONPEP

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This AOPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-242 amino acids from the N-terminal region of human AOPEP.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-AOPEP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the M1 zinc aminopeptidase
family. The encoded protein is a zinc-dependent metallopeptidase
that catalyzes the removal of an amino acid from the amino terminus
of a protein or peptide. This protein may play a role in the
generation of angiotensin IV. Alternate splicing results in
multiple transcript variants.

Cell Biology

Western Blot (WB), ELISA (EIA)

WB~~1:1000

AOPEP Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the AOPEP antibody detected the AOPEP protein (arrow).

93572

chromosome 9 open reading frame 3

aminopeptidase O

Aminopeptidase O

C9orf3; ONPEP; AP-O??[Similar Products]

AMPO_HUMAN

This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

ONPEP: Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. Belongs to the peptidase M1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.11.-

Chromosomal Location of Human Ortholog: 9q22.32

Cellular Component: cytoplasm; nucleolus

Molecular Function: zinc ion binding; metallopeptidase activity; aminopeptidase activity

Biological Process: leukotriene biosynthetic process; proteolysis

Diaz-Perales, A., et al. J. Biol. Chem. 280(14):14310-14317(2005)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)

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