Full Product Name
ASTN2 Antibody (N-term)
Product Synonym Names
Astrotactin-2; ASTN2; KIAA0634
Product Gene Name
anti-ASTN2 antibody
[Similar Products]
Antibody/Peptide Pairs
ASTN2 peptide (MBS9228579) is used for blocking the activity of ASTN2 antibody (MBS9210824)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
220-248
3D Structure
ModBase 3D Structure for O75129
Specificity
This ASTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 220-248 amino acids from the N-terminal region of human ASTN2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.42 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ASTN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASTN2 antibody
This gene encodes a protein that is expressed in the brain
and may function in neuronal migration, based on functional studies
of the related astrotactin 1 gene in human and mouse. A deletion at
this locus has been associated with schizophrenia. Multiple
transcript variants encoding different proteins have been found for
this locus.
Product Categories/Family for anti-ASTN2 antibody
Neuroscience
Applications Tested/Suitable for anti-ASTN2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ASTN2 antibody
WB~~1:1000
Western Blot (WB) of anti-ASTN2 antibody
ASTN2 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the ASTN2 antibody detected the ASTN2 protein (arrow).
NCBI/Uniprot data below describe general gene information for ASTN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_054729.3
[Other Products]
NCBI Related Accession #
MouseNP_937829.3; NP_937831.1[Other Products]
NCBI GenBank Nucleotide #
NM_014010.4
[Other Products]
UniProt Primary Accession #
O75129
[Other Products]
UniProt Secondary Accession #
Q52LQ2; Q5JVX8; Q5JVX9; Q5JVY1; Q5VXG8; Q5VZX6; Q8N6P8; Q8WV47; Q96FL4; A2A2T7; A2A2T9[Other Products]
UniProt Related Accession #
O75129[Other Products]
NCBI Official Full Name
astrotactin-2 isoform a
NCBI Official Synonym Full Names
astrotactin 2
NCBI Official Symbol
ASTN2??[Similar Products]
NCBI Official Synonym Symbols
bA67K19.1
??[Similar Products]
NCBI Protein Information
astrotactin-2
UniProt Protein Name
Astrotactin-2
Protein Family
Astrotactin
UniProt Gene Name
ASTN2??[Similar Products]
UniProt Synonym Gene Names
KIAA0634??[Similar Products]
UniProt Entry Name
ASTN2_HUMAN
NCBI Summary for ASTN2
This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]
UniProt Comments for ASTN2
ASTN2: a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus. [provided by RefSeq, May 2010]
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q33.1
Cellular Component: integral to membrane; endosome
Product References and Citations for anti-ASTN2 antibody
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Adkins, D.E., et al. Mol. Psychiatry (2010) In press :
Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008)
Vrijenhoek, T., et al. Am. J. Hum. Genet. 83(4):504-510(2008)
Research Articles on ASTN2
1. 3' terminal ASTN2 deletions are significantly enriched in males with neurodevelopmental disorders, but not in females.
Precautions
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