For Research Use Only. Not for use in diagnostic procedures.

>= 95% (SDS-PAGE)

Solution in tris-buffered sodium chloride, pH 7.5, with bromo-nitro-dioxane and methylisothiazolone as preservatives.

2-8 degree C
Do not freeze
Ships with cold packs.

Small volumes of FTL protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MyBioSource is a producer and manufacturer of human liver Ferritin for medical research and manufacturing of clinical diagnostic assays, including ones for anemia and restless leg syndrome.

Technical support, bulk quantities and aliquoting available.

Human Ferritin is a globular protein found mainly in the liver, which can store about 4,500 iron ions in a hollow shell made of 24 identical subunits. Inside the human ferritin shell, iron ions form crystallites together with phosphate and hydroxide ions.

Human Serum ferritin levels are measured in patients as part of the iron studies workup for anemia and for restless leg syndrome. Human ferritin levels have a direct correlation with the total amount of iron stored in the body. Human Ferritin levels are also indicative of the erosion of iron stores during pregnancy.

Proteins; Antigens; Standards/controls; Native Proteins; Immunogen; Ferritin

440,000

Ferritin 1 heavy chain homologue

CG2216 gene product from transcript CG2216-RA; CG2216-PA; CG2216-PB; CG2216-PC; CG2216-PD; CG2216-PE; CG2216-PF; CG2216-PG; CG2216-PI; CG2216-PJ; Fer1HCH-PA; Fer1HCH-PB; Fer1HCH-PC; Fer1HCH-PD; Fer1HCH-PE; Fer1HCH-PF; Fer1HCH-PG; Fer1HCH-PI; Fer1HCH-PJ; Ferritin-Heavy; Ferritin-Light; ferritin; ferritin 1 heavy chain; ferritin 1 heavy chain homolog; ferritin 1 heavy chain homologue; ferritin H; ferritin HCH; ferritin heavy chain; ferritin subunit 1

Ferritin light chain

Ferritin L subunit??[Similar Products]

FRIL_HUMAN

FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as *****-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.

Protein type: Oxidoreductase

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: ferritin complex; membrane; cytosol

Molecular Function: identical protein binding; protein binding; ferric iron binding; iron ion binding

Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; transmembrane transport; iron ion transport

Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3

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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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