Human Myosin-VIIa (MYO7A) ELISA kit; DFNA11; DFNB2; MYOVIIA; MYU7A; NSRD2; USH1B; deafness; autosomal dominant 11; deafness; autosomal recessive 2; myosin VIIA (Usher syndrome 1B (autosomal recessive; severe) ) ; myosin VIIA

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of MYO7A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9327216 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the myosin VIIA (MYO7A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MYO7A. The ELISA analytical biochemical technique of the MBS9327216 kit is based on MYO7A antibody-MYO7A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MYO7A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MYO7A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

254,390 Da

myosin VIIA

unconventional myosin-VIIa; myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))

Unconventional myosin-VIIa

USH1B??[Similar Products]

MYO7A_HUMAN

This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: stereocilium; photoreceptor outer segment; photoreceptor inner segment; lysosomal membrane; apical plasma membrane; cytoplasm; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium

Molecular Function: microfilament motor activity; calmodulin binding; actin filament binding; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; actin-dependent ATPase activity; ADP binding; ATP binding

Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; lysosome organization and biogenesis; actin filament-based movement; metabolic process; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis

Disease: Deafness, Autosomal Dominant 11; Deafness, Autosomal Recessive 2; Usher Syndrome, Type I

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