Coiled-coil domain-containing protein 6; Papillary thyroid carcinoma-encoded protein; Protein H4; CCDC6; D10S170; TST1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This CCDC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human CCDC6.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-CCDC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a coiled-coil domain-containing protein.
The encoded protein is ubiquitously expressed and may function as a
tumor suppressor. A chromosomal rearrangement resulting in the
expression of a fusion gene containing a portion of this gene and
the intracellular kinase-encoding domain of the ret proto-oncogene
is the cause of thyroid papillary carcinoma.

Cell Biology

Western Blot (WB), ELISA (EIA)

WB~~1:1000

CCDC6 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CCDC6 antibody detected the CCDC6 protein (arrow).

53291

coiled-coil domain containing 6

coiled-coil domain-containing protein 6

Coiled-coil domain-containing protein 6

D10S170; TST1??[Similar Products]

CCDC6_HUMAN

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.

Protein type: Apoptosis; Cytoskeletal; Oncoprotein

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein binding; structural constituent of cytoskeleton; SH3 domain binding

Disease: Thyroid Carcinoma, Papillary

Leone, V., et al. Oncogene 29(30):4341-4351(2010)
Richardson, D.S., et al. Cancer Res. 69(11):4861-4869(2009)
Jazdzewski, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105(20):7269-7274(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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