Full Product Name
ATBF1 Polyclonal Antibody
Product Gene Name
anti-ATBF1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15911
Other Notes
Small volumes of anti-ATBF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ATBF1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001158238.1
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NCBI GenBank Nucleotide #
NM_001164766.1
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UniProt Primary Accession #
Q15911
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UniProt Secondary Accession #
O15101; Q13719; D3DWS8[Other Products]
UniProt Related Accession #
Q15911[Other Products]
Molecular Weight
306,664 Da
NCBI Official Full Name
zinc finger homeobox protein 3 isoform B
NCBI Official Synonym Full Names
zinc finger homeobox 3
NCBI Official Symbol
ZFHX3??[Similar Products]
NCBI Official Synonym Symbols
ATBT; ATBF1; ZNF927
??[Similar Products]
NCBI Protein Information
zinc finger homeobox protein 3
UniProt Protein Name
Zinc finger homeobox protein 3
UniProt Synonym Protein Names
AT motif-binding factor 1; AT-binding transcription factor 1; Alpha-fetoprotein enhancer-binding protein; Zinc finger homeodomain protein 3; ZFH-3
UniProt Gene Name
ZFHX3??[Similar Products]
UniProt Synonym Gene Names
ATBF1; ZFH-3??[Similar Products]
NCBI Summary for ATBF1
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for ATBF1
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).
Research Articles on ATBF1
1. alterations in the expression and subcellular localization of ATBF1, as a result of posttranscriptional modifications, are associated with malignant features of colon tumours.
Precautions
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