Rabbit Polyclonal (IgG) to Human IKBKG / NEMO / IKK Gamma; Human IKBKG / NEMO / IKK Gamma; AMCBX1; FIP3; Fip3p; IkappaB kinase gamma; IKKgamma; IKK-gamma; NF-kappa-B essential modifier; I-kappa-B kinase gamma-subunit; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IKKAP1; Incontinentia pigmenti; IP2; IPD2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Detects endogenous levels of total IKK-gamma protein.

Immunoaffinity purified

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

1 mg/ml (lot specific)

Store at -20 degree C for up to one year.

Small volumes of anti-IKBKG / NEMO / IKK Gamma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

IKBKG Antibody, AMCBX1 Antibody, FIP3 Antibody, Fip3p Antibody, IkappaB kinase gamma Antibody, IKKgamma Antibody, IKK-gamma Antibody, NEMO Antibody, NF-kappa-B essential modifier Antibody, I-kappa-B kinase gamma-subunit Antibody, I-kappa-B kinase subunit gamma Antibody, IkB kinase gamma subunit Antibody, IKKAP1 Antibody, Incontinentia pigmenti Antibody, IP2 Antibody, IPD2 Antibody, NF-kappa-B essential modulator Antibody, ZC2HC9 Antibody, FIP-3 Antibody, IkB kinase subunit gamma Antibody, IKKG Antibody, IP1 Antibody, NFkappaB essential modulator Antibody Description: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways.

Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

ELISA (1:1000)
IF (1:100 - 1:500)
IHC-P (5 ug/ml)
WB (1:500 - 1:1000)

Anti-IKBKG / NEMO / IKK Gamma antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunofluorescence of HeLa cells, using IKK-gamma (Ab-85) Antibody. The picture on the right is treated with the synthesized peptide.

Western blot of extracts from HepG2 cells, treated with Anisomycin 0.5 uM 5h, using IKK-gamma (Ab-85) Antibody. The lane on the right is treated with the synthesized peptide.

36,953 Da

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

NF-kappa-B essential modulator

NF-kappa-B essential modulator

FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma??[Similar Products]

NEMO_HUMAN

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]

IKKG: a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2).

Protein type: Protein kinase, regulatory subunit; Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; cytosol; IkappaB kinase complex; intracellular; nucleus; spindle pole; ubiquitin ligase complex

Molecular Function: metal ion binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; signal transducer activity; ubiquitin protein ligase binding

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; apoptosis; B cell homeostasis; cell surface receptor linked signal transduction; establishment of vesicle localization; I-kappaB kinase/NF-kappaB cascade; immune response; inflammatory response; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; response to virus; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway; viral reproduction

Disease: Ectodermal Dysplasia, Anhidrotic, With Immunodeficiency, Osteopetrosis, And Lymphedema; Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency 33; Immunodeficiency Without Anhidrotic Ectodermal Dysplasia; Incontinentia Pigmenti; Invasive Pneumococcal Disease, Recurrent Isolated, 2

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