For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against CACNa1C. It has beenselected for its ability to recognize CACNa1C in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Liquid

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-CACNa1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot: Sample: Recombinant protein.

DABstainingonIHC-P.Samples:MouseTissue)

210,822 Da

calcium channel, voltage-dependent, L type, alpha 1C subunit

voltage-dependent L-type calcium channel subunit alpha-1C

Voltage-dependent L-type calcium channel subunit alpha-1C

Cach2; Cacn2; Cacnl1a1; Cchl1a1; MBC??[Similar Products]

CACNA1C: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function. Defects in CACNA1C are the cause of Timothy syndrome (TS). TS is a disorder characterized by multiorgan dysfunction including lethal arrhythmias, webbing of fingers and toes, congenital heart disease, immune deficiency, intermittent hypoglycemia, cognitive abnormalities and autism. Defects in CACNA1C are the cause of Brugada syndrome type 3 (BRGDA3). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. 35 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6 F1|6 55.86 cM

Cellular Component: caveolar macromolecular signaling complex; cell soma; cytoplasm; dendrite; dendritic shaft; integral component of membrane; L-type voltage-gated calcium channel complex; membrane; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane; protein complex; sarcolemma; T-tubule; voltage-gated calcium channel complex; Z disc

Molecular Function: alpha-actinin binding; calcium channel activity; enzyme binding; high voltage-gated calcium channel activity; ion channel activity; ion channel binding; metal ion binding; protein binding; protein domain specific binding; protein phosphatase 2A binding; translation initiation factor binding; voltage-gated calcium channel activity; voltage-gated calcium channel activity involved in AV node cell action potential; voltage-gated calcium channel activity involved in cardiac muscle cell action potential; voltage-gated ion channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential

Biological Process: ***** walking behavior; calcium ion transport; calcium ion-dependent exocytosis; camera-type eye development; cardiac muscle cell action potential involved in contraction; cellular calcium ion homeostasis; elevation of cytosolic calcium ion concentration; embryonic forelimb morphogenesis; glucose homeostasis; growth hormone secretion; heart development; immune system development; insulin secretion; ion transport; membrane depolarization during action potential; membrane depolarization during atrial cardiac muscle cell action potential; membrane depolarization during AV node cell action potential; membrane depolarization during cardiac muscle cell action potential; regulation of blood pressure; regulation of heart rate by cardiac conduction; regulation of ion transmembrane transport; regulation of organ growth; regulation of vasoconstriction; regulation of ventricular cardiac muscle cell action potential; smooth muscle contraction; smooth muscle contraction involved in micturition; synaptic transmission; transmembrane transport; transport; visual learning

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