Full Product Name
CALCA Polyclonal Antibody
Product Synonym Names
CALC1; CGRP; CGRP-I; CGRP1; CT; KC; PCT
Product Gene Name
anti-CALCA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01258
Purity/Purification
Affinity Purification
Immunogen
A synthetic peptide of human CALCA
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at 4 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CALCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CALCA antibody
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-CALCA antibody
Primary antibody
Applications Tested/Suitable for anti-CALCA antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CALCA antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
Western Blot (WB) of anti-CALCA antibody
Western blot analysis of extracts of various cell lines, using CALCA antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
NCBI/Uniprot data below describe general gene information for CALCA. It may not necessarily be applicable to this product.
NCBI Accession #
P01258.2
[Other Products]
UniProt Primary Accession #
P01258
[Other Products]
UniProt Secondary Accession #
Q13935; Q13937; Q52LX7; B7ZL39[Other Products]
UniProt Related Accession #
P01258; P06881[Other Products]
NCBI Official Full Name
Calcitonin
NCBI Official Synonym Full Names
calcitonin related polypeptide alpha
NCBI Official Symbol
CALCA??[Similar Products]
NCBI Official Synonym Symbols
CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
??[Similar Products]
NCBI Protein Information
calcitonin; calcitonin gene-related peptide 1
UniProt Protein Name
Calcitonin
UniProt Synonym Protein Names
CalcitoninKatacalcinAlternative name(s):Calcitonin carboxyl-terminal peptide; CCP
Protein Family
Calcitonin
UniProt Gene Name
CALCA??[Similar Products]
UniProt Synonym Gene Names
CALC1; CCP??[Similar Products]
NCBI Summary for CALCA
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
UniProt Comments for CALCA
CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: extracellular region; extracellular space
Molecular Function: calcitonin receptor binding; identical protein binding; protein binding
Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity
Research Articles on CALCA
1. the prognostic value of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), and pancreatic stone protein (PSP) in children with sepsis, was investigated.
Precautions
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Disclaimer
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