Product Name
Ferritin Light Chain (FTL), Recombinant Protein
Popular Item
Full Product Name
Ferritin Light Chain Recomb.
Product Gene Name
FTL recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
> 95% pure (PAGE). Heat treatment purification.
Form/Format
Purified, Liquid
Concentration
5.26 mg/mL Centaur Ferritin Assay (lot specific)
Buffer
Phosphate Buffered Saline, pH 7.4 ± 0.2
Important Note
Centrifuge before opening to ensure complete recovery of vial contents
Preparation and Storage
Store at 2-8 degree C. For long term, aliquot and store at -20 degree C to avoid multiple/freeze thaw cycles.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FTL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FTL recombinant protein
Ferritin Light Chain Recomb.
Ferritin Light Chain Recombinant
NCBI reference number: NM 000146.3
185 a.a. in length. There is no fusion tag included in this product.
Centaur Ferritin/Vitamin B12 Ratio - > 5,260,000
Cobas Ferritin/Vitamin B12 Ratio - 4,500,000
Cobas CEA Assay - Lot Specific
Centaur CEA Assay - Lot Specific
Cobas Ferritin Assay - Lot Specific
Cobas B12 Assay - Lot Specific
Product Categories/Family for FTL recombinant protein
Purified Proteins and Bioactive Peptides
Applications Tested/Suitable for FTL recombinant protein
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FTL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000137.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000146.3
[Other Products]
UniProt Secondary Accession #
Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8; B2R4B9[Other Products]
UniProt Related Accession #
P02792[Other Products]
NCBI Official Full Name
ferritin light chain
NCBI Official Synonym Full Names
ferritin, light polypeptide
NCBI Official Symbol
FTL??[Similar Products]
NCBI Official Synonym Symbols
LFTD; NBIA3
??[Similar Products]
NCBI Protein Information
ferritin light chain
UniProt Protein Name
Ferritin light chain
UniProt Gene Name
FTL??[Similar Products]
UniProt Synonym Gene Names
Ferritin L subunit??[Similar Products]
UniProt Entry Name
FRIL_HUMAN
NCBI Summary for FTL
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Comments for FTL
FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as *****-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: cytosol; ferritin complex; membrane
Molecular Function: ferric iron binding; identical protein binding; iron ion binding; protein binding
Biological Process: cellular iron ion homeostasis; iron ion homeostasis; iron ion transport; post-Golgi vesicle-mediated transport; receptor-mediated endocytosis; transmembrane transport
Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3
Research Articles on FTL
1. Single nucleotide polymorphisms in HAMP, BMP2, FTL and SLC40A1 genes have phenotype-modifying roles in hereditary hemochromatosis type 1.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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