Full Product Name
Phospho-Lamin A/C (Ser392) Antibody
Product Gene Name
anti-LMNA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02545
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-LMNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LMNA antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
NCBI/Uniprot data below describe general gene information for LMNA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001244303.1
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NCBI GenBank Nucleotide #
NM_001257374.2
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UniProt Primary Accession #
P02545
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UniProt Secondary Accession #
P02546; Q5I6Y4; Q5I6Y6; Q5TCJ2; Q5TCJ3; Q6UYC3; Q969I8; B4DI32; D3DVB0; D6RAQ3; E7EUI9[Other Products]
UniProt Related Accession #
P02545[Other Products]
Molecular Weight
69,249 Da[Similar Products]
NCBI Official Full Name
lamin isoform D
NCBI Official Synonym Full Names
lamin A/C
NCBI Official Symbol
LMNA??[Similar Products]
NCBI Official Synonym Symbols
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; MADA; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
??[Similar Products]
NCBI Protein Information
lamin
UniProt Protein Name
Prelamin-A/C
UniProt Synonym Protein Names
Lamin-A/CAlternative name(s):70 kDa lamin; Renal carcinoma antigen NY-REN-32
UniProt Gene Name
LMNA??[Similar Products]
UniProt Synonym Gene Names
LMN1??[Similar Products]
NCBI Summary for LMNA
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
UniProt Comments for LMNA
lamin A/C: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasm; cytosol; extracellular matrix; nuclear envelope; nuclear membrane; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: establishment and/or maintenance of microtubule cytoskeleton polarity; mitotic nuclear envelope disassembly; mitotic nuclear envelope reassembly; regulation of cell migration
Disease: Cardiomyopathy, Dilated, 1a; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism; Charcot-marie-tooth Disease, Axonal, Type 2b1; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Heart-hand Syndrome, Slovenian Type; Hutchinson-gilford Progeria Syndrome; Lipodystrophy, Familial Partial, Type 2; Mandibuloacral Dysplasia With Type A Lipodystrophy; Muscular Dystrophy, Congenital, Lmna-related; Muscular Dystrophy, Limb-girdle, Type 1b; Restrictive Dermopathy, Lethal
Research Articles on LMNA
1. G in the LMNA gene is new intronic splicing mutation which is responsible for progressive cardiac conduction defects and variable myopathy.">Variant c.513+45T>G in the LMNA gene is new intronic splicing mutation which is responsible for progressive cardiac conduction defects and variable myopathy.
Precautions
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Disclaimer
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