Full Product Name
Chicken CALCA Polyclonal Antibody
Product Synonym Names
CALC
Product Gene Name
anti-CALCA antibody
[Similar Products]
Matching Pairs
Antibody: CALCA (MBS2895453)
Antigen: Calcitonin gene-related peptide 1 (MBS2889033)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06881
Species Reactivity
Human, Rat
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human CALCA Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-CALCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CALCA antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CALCA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001029125.1
[Other Products]
NCBI GenBank Nucleotide #
NP_001029125.1
[Other Products]
UniProt Primary Accession #
P06881
[Other Products]
UniProt Related Accession #
P01258; P06881[Other Products]
NCBI Official Full Name
calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein
NCBI Official Synonym Full Names
calcitonin related polypeptide alpha
NCBI Official Symbol
CALCA??[Similar Products]
NCBI Official Synonym Symbols
CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I
??[Similar Products]
NCBI Protein Information
calcitonin; calcitonin gene-related peptide 1
UniProt Protein Name
Calcitonin gene-related peptide 1
UniProt Synonym Protein Names
Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
Protein Family
Calcitonin
UniProt Gene Name
CALCA??[Similar Products]
UniProt Synonym Gene Names
CALC1; CGRP-I??[Similar Products]
UniProt Entry Name
CALCA_HUMAN
NCBI Summary for CALCA
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
UniProt Comments for CALCA
CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: extracellular region; extracellular space
Molecular Function: calcitonin receptor binding; identical protein binding; protein binding
Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity
Research Articles on CALCA
1. patients with C/C genotype may have reduced sensitivity to fentanyl analgesia and/or increased pain perception.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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