Product Name
Lamin A/C (LMNA), Polyclonal Antibody
Full Product Name
Lamin A/C Rabbit pab Antibody
Product Synonym Names
LMNA; LMNA; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; LD P1; LFP; LGMD1B; LMN1; LMNC; PRO1 ;
Product Gene Name
anti-LMNA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (156052369..156109880). Location: 1q22
3D Structure
ModBase 3D Structure for P02545
Species Reactivity
Human, mouse, rat
Purity/Purification
Affinity purification
Immunogen
A fusion protein of human Lamin A/C
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol,
Preparation and Storage
Upon delivery aliquot and store at -20 degree C or -80 degree C.
Other Notes
Small volumes of anti-LMNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LMNA antibody
Rabbit polyclonal to Human Lamin A/C
Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear disregulation and cell death (5,6).
Applications Tested/Suitable for anti-LMNA antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-LMNA antibody
Western Blot (WB): 1/500-1000
Immunofluorescence (IF): 1/20-50
Western Blot (WB) of anti-LMNA antibody
Western blot analysis of extracts of NCI-H293 cells, using LMNA antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
NCBI/Uniprot data below describe general gene information for LMNA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001244303.1
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NCBI GenBank Nucleotide #
NM_001257374.1
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UniProt Primary Accession #
P02545
[Other Products]
UniProt Secondary Accession #
P02546; Q5TCJ2; Q5TCJ3; Q969I8; Q96JA2; B4DI32; D3DVB0; E7EUI9[Other Products]
UniProt Related Accession #
P02545[Other Products]
Molecular Weight
664[Similar Products]
NCBI Official Full Name
lamin isoform D
NCBI Official Synonym Full Names
lamin A/C
NCBI Official Symbol
LMNA??[Similar Products]
NCBI Official Synonym Symbols
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
??[Similar Products]
NCBI Protein Information
lamin; 70 kDa lamin; prelamin-A/C; lamin A/C-like 1; renal carcinoma antigen NY-REN-32
UniProt Protein Name
Prelamin-A/C
UniProt Synonym Protein Names
70 kDa lamin; Renal carcinoma antigen NY-REN-32
UniProt Gene Name
LMNA??[Similar Products]
UniProt Synonym Gene Names
LMN1??[Similar Products]
UniProt Entry Name
LMNA_HUMAN
Product References and Citations for anti-LMNA antibody
1. Gruenbaum, Y. et al. (2000) J Struct Biol 129, 313-23. 2. Yabuki, M. et al. (1999) Physiol Chem Phys Med NMR 31, 77-84. 3. Goldberg, M. et al. (1999) Crit Rev Eukaryot Gene Expr 9, 285-93. 4. Orth, K. et al. (1996) J Biol Chem 271, 16443-6. 5. Oberhammer, F.A. et al. (1994) J Cell Biol 126, 827-37. 6. Rao, L. et al. (1996) J Cell Biol 135, 1441-55.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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