Product Name
Ferritin Light Chain (FTL), Monoclonal Antibody
Full Product Name
Ferritin Light Chain antibody
Product Synonym Names
Monoclonal Ferritin Light Chain; Anti-Ferritin Light Chain; FTL; ferritin; light polypeptide; BOS_17615; EGK_10864; ferritin L-chain; ferritin light chain; ferritin light chain 1; ferritin light chain 2; ferritin light polypeptide-like 3; ferritin L subunit; ferritin L subunit 1; ferritoid; FT; FTD; Ftl1; FTL2; NBIA3
Product Gene Name
anti-FTL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02792
Purity/Purification
Ferritin Light Chain antibody was purified by ammonium sulfate precipitation
Form/Format
Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
Biological Significance
Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis. It is a holoenzyme shell (~450 kDa) consisting of 24 subunits of two types, H (heavy) and L (light), and capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiologic status of the cell, the ratio of H to L subunits in ferritin can vary widely. It can be viewed not only as part of a group of iron regulatory proteins that include transferrin and the transferrin receptor, but also as a member of the protein family that orchestrates the cellular defense against stress and inflammation. Ferritin is found in the liver, spleen, kidney and heart. Only a small amount is found in the blood. The blood level of ferritin serves as an indicator of the amount of iron stored in the body.
Immunogen
Ferritin Light Chain antibody was raised in Mouse using a recombinant human protein purified from E Coli (His-FL) as the immunogen
Preparation and Storage
Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles
Other Notes
Small volumes of anti-FTL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FTL antibody
Mouse monoclonal Ferritin Light Chain antibody
Product Categories/Family for anti-FTL antibody
Neuroscience
Applications Tested/Suitable for anti-FTL antibody
Western Blot (WB)
Application Notes for anti-FTL antibody
WB: 1:5000
Western Blot (WB) of anti-FTL antibody
NCBI/Uniprot data below describe general gene information for FTL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000137.2
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NCBI GenBank Nucleotide #
NM_000146.3
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UniProt Primary Accession #
P02792
[Other Products]
UniProt Secondary Accession #
Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8; B2R4B9[Other Products]
UniProt Related Accession #
P02792[Other Products]
Molecular Weight
20,020 Da[Similar Products]
NCBI Official Full Name
ferritin light chain
NCBI Official Synonym Full Names
ferritin, light polypeptide
NCBI Official Symbol
FTL??[Similar Products]
NCBI Official Synonym Symbols
LFTD; NBIA3
??[Similar Products]
NCBI Protein Information
ferritin light chain
UniProt Protein Name
Ferritin light chain
UniProt Gene Name
FTL??[Similar Products]
UniProt Synonym Gene Names
Ferritin L subunit??[Similar Products]
UniProt Entry Name
FRIL_HUMAN
NCBI Summary for FTL
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
UniProt Comments for FTL
FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as *****-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: ferritin complex; membrane; cytosol
Molecular Function: identical protein binding; protein binding; ferric iron binding; iron ion binding
Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; iron ion transport; transmembrane transport
Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3
Research Articles on FTL
1. Urine ferritin levels are elevated significantly in systemic lupus erythematosus and correlate with disease activity.
Precautions
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