Anti -MCP4 (Macrophage/Monocyte Chemotactic Protein 4) (Biotin)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 17; NC_000017.10 (32683471..32685629). Location: 17q11.2

Polyclonal

IgG

Rabbit

Recognizes MCP-4

Affinity Purified
Purified by immobilized antigen affinity chromatography.

A sterile filtered antibody solution (1mg/ml) was lyophilized from 0.5X PBS, pH 7.4. Conjugated to Biotin.

-20 degree C

Small volumes of anti-CCL13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Growth Factors, Cytokines

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Neutralization

Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity (50ng/ml), a concentration of 1.75-3.0ug/ml of this antibody is required.
ELISA: Detection by direct ELISA (using 100ul/well antibody solution), requires a concentration of at least 0.5ug/ml of antibody. This antigen-affinity purified antibody, in conjunction with compatible secondary reagents, allows detection of 0.2-0.4ng/well.
Immunohistochemistry: To be determined by the researcher.
Western Blot: Use at a concentration of 0.1-0.2ug/ml. Used in conjunction with compatible secondary reagents the detection limit is 1.5-3.0ng/lane, under either reducing or non-reducing conditions.

10,986 Da[Similar Products]

chemokine (C-C motif) ligand 13

C-C motif chemokine 13; CK-beta-10; OTTHUMP00000163804; new CC chemokine 1; small-inducible cytokine A13; monocyte chemotactic protein 4; monocyte chemoattractant protein 4; small inducible cytokine subfamily A (Cys-Cys), member 13

C-C motif chemokine 13

MCP4; NCC1; SCYA13??[Similar Products]

CCL13_HUMAN

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq]

CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Chemokine

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: extracellular space

Molecular Function: chemokine activity; receptor binding

Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; cytoskeleton organization and biogenesis; immune response; inflammatory response; signal transduction; chemotaxis

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