Full Product Name
PANK2 Antibody
Product Gene Name
anti-PANK2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BZ23
Specificity
PANK2 antibody detects endogenous levels of PANK2.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human PANK2.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-PANK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PANK2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PANK2 antibody
WB: 1:500~1:1000
ELISA: 1:10000
Western Blot (WB) of anti-PANK2 antibody
Western blot analysis of lysates from A549 cells, using PANK2 antibody.
NCBI/Uniprot data below describe general gene information for PANK2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001311120.1
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NCBI GenBank Nucleotide #
NM_001324191.1
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UniProt Primary Accession #
Q9BZ23
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UniProt Secondary Accession #
Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9HAF2; B1AK33; B2Z3X0; D3DVZ0[Other Products]
UniProt Related Accession #
Q9BZ23[Other Products]
NCBI Official Full Name
pantothenate kinase 2, mitochondrial isoform 2
NCBI Official Synonym Full Names
pantothenate kinase 2
NCBI Official Symbol
PANK2??[Similar Products]
NCBI Official Synonym Symbols
HSS; HARP; PKAN; NBIA1; C20orf48
??[Similar Products]
NCBI Protein Information
pantothenate kinase 2, mitochondrial
UniProt Protein Name
Pantothenate kinase 2, mitochondrial
UniProt Synonym Protein Names
Pantothenic acid kinase 2
Protein Family
Pantothenate kinase
UniProt Gene Name
PANK2??[Similar Products]
UniProt Synonym Gene Names
C20orf48; hPanK2??[Similar Products]
NCBI Summary for PANK2
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for PANK2
May be the master regulator of the CoA biosynthesis.
Research Articles on PANK2
1. PANK2 mutations have an effect on iPSC-derived cortical neuronal cells in culture
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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