Product Name
PANK2, Polyclonal Antibody
Popular Item
Full Product Name
PANK2 Antibody
Product Synonym Names
4933409I19Rik; AI642621; C20orf48; Hallervorden Spatz syndrome; HARP; hPANK2; HSS; MGC118448; MGC15053; mitochondrial; NBIA1; PANK2; PANK2_HUMAN; Pantothenate kinase 2 (Hallervorden Spatz syndrome); Pantothenate kinase 2; Pantothenate kinase 2 mitochondrial; Pantothenic acid kinase 2; PKAN; RP23 387C21.4
Product Gene Name
anti-PANK2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BZ23
Specificity
PANK2 antibody detects endogenous levels of total PANK2
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human PANK2
Subcellular Location
Cytoplasm and Mitochondrion.
Tissue Specificity
Ubiquitous.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-PANK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PANK2 antibody
Function: May be the master regulator of the CoA biosynthesis.
Subunit Structure: Homodimer.
Similarity: Belongs to the type II pantothenate kinase family.
Applications Tested/Suitable for anti-PANK2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PANK2 antibody
WB: 1:1000-3000
Western Blot (WB) of anti-PANK2 antibody
Western blot analysis of PANK2 using HT29 whole cell lysates
NCBI/Uniprot data below describe general gene information for PANK2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001311120.1
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NCBI GenBank Nucleotide #
NM_001324191.1
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UniProt Primary Accession #
Q9BZ23
[Other Products]
UniProt Secondary Accession #
Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9HAF2; B1AK33; B2Z3X0; D3DVZ0[Other Products]
UniProt Related Accession #
Q9BZ23[Other Products]
Molecular Weight
Observed: 62 kDa
Predicted: 63 kDa
NCBI Official Full Name
pantothenate kinase 2, mitochondrial isoform 2
NCBI Official Synonym Full Names
pantothenate kinase 2
NCBI Official Symbol
PANK2??[Similar Products]
NCBI Official Synonym Symbols
HSS; HARP; PKAN; NBIA1; C20orf48
??[Similar Products]
NCBI Protein Information
pantothenate kinase 2, mitochondrial
UniProt Protein Name
Pantothenate kinase 2, mitochondrial
UniProt Synonym Protein Names
Pantothenic acid kinase 2
Protein Family
Pantothenate kinase
UniProt Gene Name
PANK2??[Similar Products]
UniProt Synonym Gene Names
C20orf48; hPanK2??[Similar Products]
NCBI Summary for PANK2
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for PANK2
May be the master regulator of the CoA biosynthesis.
Research Articles on PANK2
1. T (p.Glu322Asp) mutation in the PANK2 gene mutation analysis in the individuals from the brain imaging findings. Although individuals in this family who had a homozygous mutation in PANK2 gene analyses had the 'eye-of-the-tiger' sign and atypical disease, they were noted to have differing clinical findings.">We found c.966 G>T (p.Glu322Asp) mutation in the PANK2 gene mutation analysis in the individuals from the brain imaging findings. Although individuals in this family who had a homozygous mutation in PANK2 gene analyses had the 'eye-of-the-tiger' sign and atypical disease, they were noted to have differing clinical findings.
Precautions
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Disclaimer
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