Product Name
ABHD12, Polyclonal Antibody
Full Product Name
ABHD12 Polyclonal Antibody
Product Gene Name
anti-ABHD12 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8N2K0
Other Notes
Small volumes of anti-ABHD12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ABHD12. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001035937.1
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NCBI GenBank Nucleotide #
NM_001042472.2
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UniProt Primary Accession #
Q8N2K0
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UniProt Secondary Accession #
Q5T710; Q5T711; Q96CR1; Q9BX05; Q9NPX7; Q9UFV6; A6NED4; A6NJ90; A8K450; B4DE71[Other Products]
UniProt Related Accession #
Q8N2K0[Other Products]
Molecular Weight
41,387 Da
NCBI Official Full Name
monoacylglycerol lipase ABHD12 isoform a
NCBI Official Synonym Full Names
abhydrolase domain containing 12
NCBI Official Symbol
ABHD12??[Similar Products]
NCBI Official Synonym Symbols
PHARC; ABHD12A; BEM46L2; C20orf22; dJ965G21.2
??[Similar Products]
NCBI Protein Information
monoacylglycerol lipase ABHD12
UniProt Protein Name
Monoacylglycerol lipase ABHD12
UniProt Synonym Protein Names
2-arachidonoylglycerol hydrolaseCurated; Abhydrolase domain-containing protein 12Curated
Protein Family
Monoacylglycerol lipase
UniProt Gene Name
ABHD12??[Similar Products]
NCBI Summary for ABHD12
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
UniProt Comments for ABHD12
Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain (). May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways.
Research Articles on ABHD12
1. This study presented the various mutation of ABHD12 responsible for PHARC syndrome.
Precautions
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Disclaimer
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