Rabbit Polyclonal (IgG) to Human ABHD12; Human ABHD12; ABHD12A; BEM46L2; C20orf22; DKFZP434P106; PHARC; DJ965G21.2; Monoacylglycerol lipase ABHD12

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

ABHD12 Antibody detects endogenous levels of total ABHD12 protein.

Immunoaffinity purified

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

Store at -20 degree C for up to one year.

Small volumes of anti-ABHD12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ABHD12 Antibody, ABHD12A Antibody, BEM46L2 Antibody, C20orf22 Antibody, DKFZP434P106 Antibody, PHARC Antibody, DJ965G21.2 Antibody, Monoacylglycerol lipase ABHD12 Antibody Description: ABHD12 is an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation.

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)

ELISA (1:40000)
IHC-P (10 ug/ml)
WB (1:500 - 1:1000)

Anti-ABHD12 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Western blot of extracts from COLO cells, using ABHD12 Antibody. The lane on the right is treated with the synthesized peptide.

41,387 Da

abhydrolase domain containing 12

monoacylglycerol lipase ABHD12

Monoacylglycerol lipase ABHD12

ABD12_HUMAN

This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]

ABHD12: Has 2-arachidonoylglycerol hydrolase activity. May be a regulator of endocannabinoid signaling pathways. Defects in ABHD12 are the cause of polyneuropathy hearing loss ataxia retinitis pigmentosa and cataract (PHARC). PHARC is a slowly progressive neurologic disorder with a variable phenotype resembling Refsum disease. Clinical features include sensorineural hearing loss, visual problems related to cataracts, retinitis pigmentosa, pes cavus, ataxic and/or spastic gait disturbances with a progressive sensorimotor peripheral neuropathy. Other features include hyporeflexia, hyperreflexia, extensor plantar responses. Belongs to the serine esterase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Membrane protein, integral; EC 3.1.1.23

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: acylglycerol lipase activity

Biological Process: acylglycerol catabolic process; ***** walking behavior; blood coagulation; phosphatidylserine catabolic process; platelet activation

Disease: Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.