OAT4; Solute carrier family 22 member 11; Organic anion transporter 4

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of SLC22A11 protein.

The antibody was purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-SLC22A11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to SLC22A11

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

WB: 1/500 - 1/2000; IF/ICC: 1/50 - 1/100

Western blot analysis of SLC22A11 expression in SW620 (A), HepG2 (B), mouse liver (C), rat kidney (D) whole cell lysates.

Immunofluorescent analysis of SLC22A11 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.

48,301 Da

solute carrier family 22 member 11

solute carrier family 22 member 11

Solute carrier family 22 member 11

OAT4??[Similar Products]

S22AB_HUMAN

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

SLC22A11: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter; Cell surface

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: apical plasma membrane; external side of plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: inorganic anion exchanger activity; organic anion transmembrane transporter activity; protein binding; sodium-independent organic anion transmembrane transporter activity

Biological Process: organic anion transport; sodium-independent organic anion transport; urate metabolic process

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