Product Name
Solute Carrier Family 22, Member 11 (SLC22A11), Recombinant Protein
Full Product Name
Recombinant Solute Carrier Family 22, Member 11 (SLC22A11)
Product Synonym Names
OAT4; hOAT4; Organic Anion/Urate Transporter 11; Organic anion transporter 4
Product Gene Name
SLC22A11 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NSA0
Purity/Purification
> 95%
Form/Format
Freeze-dried powder
Buffer Formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Source Note
Prokaryotic expression
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
Subcellular Location
Cell Membrane; Multi-pass Membrane Protei
Usage
Reconstitute in PBS or others.
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of SLC22A11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for SLC22A11 recombinant protein
Recombinant Protein
Applications Tested/Suitable for SLC22A11 recombinant protein
Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
SDS-Page of SLC22A11 recombinant protein
NCBI/Uniprot data below describe general gene information for SLC22A11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001294914.1
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NCBI GenBank Nucleotide #
NM_001307985.1
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UniProt Primary Accession #
Q9NSA0
[Other Products]
UniProt Secondary Accession #
Q53GR2; Q6ZP72; Q8NBU4; A8K426[Other Products]
UniProt Related Accession #
Q9NSA0[Other Products]
NCBI Official Full Name
solute carrier family 22 member 11 isoform 2
NCBI Official Synonym Full Names
solute carrier family 22 member 11
NCBI Official Symbol
SLC22A11??[Similar Products]
NCBI Official Synonym Symbols
OAT4; hOAT4
??[Similar Products]
NCBI Protein Information
solute carrier family 22 member 11
UniProt Protein Name
Solute carrier family 22 member 11
UniProt Synonym Protein Names
Organic anion transporter 4
Protein Family
Solute carrier family
UniProt Gene Name
SLC22A11??[Similar Products]
UniProt Synonym Gene Names
OAT4??[Similar Products]
NCBI Summary for SLC22A11
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Comments for SLC22A11
SLC22A11: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: apical plasma membrane; external side of plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: inorganic anion exchanger activity; organic anion transmembrane transporter activity; protein binding; sodium-independent organic anion transmembrane transporter activity
Biological Process: organic anion transport; sodium-independent organic anion transport; urate metabolic process
Research Articles on SLC22A11
1. The first genome-wide association study for serum uric acid level in Indians revealed association of SLC2A9, SLC22A11 and ABCG2 gene variants at genome wide significance level in Type 2 diabetes patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.