Human WD repeat domain phosphoinositide-interacting protein 4 (WDR45) ELISA kit; JM5; WDRX1; WIPI-4; WIPI4; WD repeat domain; X-linked 1; WD45 repeat protein interacting with phosphoinositides 4; WD repeat domain 45

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of WDR45 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9320162 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the WD repeat domain 45 (WDR45) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing WDR45. The ELISA analytical biochemical technique of the MBS9320162 kit is based on WDR45 antibody-WDR45 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect WDR45 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, WDR45. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

39,868 Da

WD repeat domain 45

WD repeat domain phosphoinositide-interacting protein 4; WD repeat domain, X-linked 1; WD repeat-containing protein 45; neurodegeneration with brain iron accumulation 4; neurodegeneration with brain iron accumulation 5; WD45 repeat protein interacting with phosphoinositides 4

WD repeat domain phosphoinositide-interacting protein 4

WDRX1; WDRXI4; WIPI4; JM5; WIPI-4??[Similar Products]

WIPI4_HUMAN

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

WDR45: a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Protein type: Autophagy

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: extrinsic to membrane; pre-autophagosomal structure membrane; cytosol

Molecular Function: phosphatidylinositol 3-phosphate binding

Biological Process: mitochondrion degradation; protein amino acid lipidation; autophagy; cellular response to nitrogen starvation; autophagic vacuole formation

Disease: Neurodegeneration With Brain Iron Accumulation 5

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