For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified by protein affinity column containing 1% BSA and 0.02% NaN3

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

Small volumes of anti-WDR45 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal WDR45 (1) antibody was raised against a recombinate human WDR45 protein 11-186aa (BC000464).

ELISA (EIA), Immunohistochemistry (IHC)

ELISA: 1:20,000-1:80,000
IHC: 1:100-1:500

39,939 Da

WD repeat domain 45

WD repeat domain phosphoinositide-interacting protein 4

WD repeat domain phosphoinositide-interacting protein 4

WDRX1; WDRXI4; WIPI4; WIPI-4??[Similar Products]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.

(1) Haack, T.B., Hogarth, P., Kruer, M.C., et al. Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA. Am. J. Hum. Genet. 91 (6), 1144-1149 (2012).

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