WD repeat domain phosphoinositide-interacting protein 4; WIPI-4; WD repeat-containing protein 45; WDR45; WDRX1; WDRXI4; WIPI4; JM5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-WDR45 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.

ELISA (EIA), Immunohistochemistry (IHC)

Recommended dilution: IHC: 1:20-1:200

Immunohistochemistry of paraffin-embedded human liver tissue using MBS7044362 at dilution of 1:100

39,939 Da

WD repeat domain 45

WD repeat domain phosphoinositide-interacting protein 4

WD repeat domain phosphoinositide-interacting protein 4

WDRX1; WDRXI4; WIPI4; WIPI-4??[Similar Products]

WIPI4_HUMAN

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

WDR45: a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity and full-length nature of some variants have not been determined. [provided by RefSeq, Jul 2008]

Protein type: Autophagy

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytosol; extrinsic to membrane; pre-autophagosomal structure membrane

Molecular Function: phosphatidylinositol 3-phosphate binding

Biological Process: autophagic vacuole formation; autophagy; mitochondrion degradation; protein amino acid lipidation

Disease: Neurodegeneration With Brain Iron Accumulation 5

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