SGCG; sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); A4; DAGA4; DMDA; DMDA1; LGMD2C; MAM; MGC130048; SCARMD2; SCG3; TYPE; 35kD dystrophin-associated glycoprotein; Maghrebian myopathy (autosomal recessive); OTTHUMP00000018112; gamma sarcogl; SGCG antibody; sarcoglycan; gamma (35kDa dystrophin-associated glycoprotein) antibody; A4 antibody; DAGA4 antibody; DMDA antibody; DMDA1 antibody; LGMD2C antibody; MAM antibody; MGC130048 antibody; SCARMD2 antibody; SCG3 antibody; TYPE antibody; 35kD dystrophin-associated glycoprotein antibody; Maghrebian myopathy (autosomal recessive) antibody; OTTHUMP00000018112 antibody; gamma sarcoglycan antibody; limb girdle muscular dystrophy 2C (Duchenne-like muscular dystrophy; autosomal recessive) antibody; sarcoglycan; gamma (35kD dystrophin-associated glycoprotein) antibody; gamma sarcoglycan; gamma sarcoglycan

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-SGCG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Preliminary experiments gave an approx 45kDa band in Human Heart lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 32.4kDa according to NP_000222.1. The 45kDa band was successfully blocked by incubation with the immunizing peptide.

32,379 Da

sarcoglycan gamma

gamma-sarcoglycan

Gamma-sarcoglycan

Gamma-SG; 35DAG??[Similar Products]

SGCG_HUMAN

This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]

SGCG: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterized by progressive muscle wasting from early childhood. Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Protein type: Membrane protein, integral; Dystrophin complex

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: cytoplasm; cytoskeleton; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma

Molecular Function: protein binding

Biological Process: cardiac muscle development; heart contraction; muscle cell development; muscle development

Disease: Muscular Dystrophy, Limb-girdle, Type 2c

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