Product Name
Major prion (PRNP), Protein
Full Product Name
Major prion protein
Product Synonym Names
Prn-p; Prp; PrP27-30; PrP33-35C; CD230
Product Gene Name
PRNP protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
23-230aa
3D Structure
ModBase 3D Structure for P04925
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of PRNP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for PRNP protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for PRNP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001265185.1
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NCBI GenBank Nucleotide #
NM_001278256.1
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UniProt Primary Accession #
P04925
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UniProt Related Accession #
P04925[Other Products]
Molecular Weight
27,977 Da
NCBI Official Full Name
major prion protein
NCBI Official Synonym Full Names
prion protein
NCBI Official Symbol
Prnp??[Similar Products]
NCBI Official Synonym Symbols
PrP; PrPC; Sinc; CD230; PrPSc; Prn-i; Prn-p; PrP; AA960666; AI325101; prP27-30; prP33-35C
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NCBI Protein Information
major prion protein
UniProt Protein Name
Major prion protein
UniProt Synonym Protein Names
PrP27-30; PrP33-35C; CD_antigen: CD230
Protein Family
Major prion protein
UniProt Gene Name
Prnp??[Similar Products]
UniProt Synonym Gene Names
Prn-p; Prp; PrP??[Similar Products]
UniProt Comments for PRNP
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (PubMed:12732622, PubMed:16492732, PubMed:19242475, PubMed:19568430).
Research Articles on PRNP
1. Furthermore, our finding that a relatively short beta-sheet core of PrP23-144 fibrils (residues approximately 112-139) with a parallel in-register organization of beta-strands is capable of seeding the conversion of full-length prion protein to the infectious form has important implications for the ongoing debate regarding structural aspects of prion protein conversion and molecular architecture of mammalian prions.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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