Product Name
gamma sarcoglycan (SGCG), Blocking Peptide
Full Product Name
gamma sarcoglycan Immunizing Peptide
Product Synonym Names
SGCG; sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); A4; DAGA4; DMDA; DMDA1; LGMD2C; MAM; MGC130048; SCARMD2; SCG3; TYPE; 35kD dystrophin-associated glycoprotein; Maghrebian myopathy (autosomal recessive); OTTHUMP00000018112; gamma sarcogl; gamma sarcoglycan; gamma sarcoglycan
Product Gene Name
SGCG blocking peptide
[Similar Products]
gamma sarcoglycan peptide (MBS426464) is used for blocking the activity of gamma sarcoglycan antibody (MBS422202)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-NQQFQINS NDGKP
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of SGCG blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SGCG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000222.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000231.2
[Other Products]
UniProt Secondary Accession #
Q32M32; Q5T9J6[Other Products]
UniProt Related Accession #
Q13326[Other Products]
Molecular Weight
32,379 Da
NCBI Official Full Name
gamma-sarcoglycan
NCBI Official Synonym Full Names
sarcoglycan gamma
NCBI Official Symbol
SGCG??[Similar Products]
NCBI Official Synonym Symbols
A4; MAM; DMDA; SCG3; 35DAG; DAGA4; DMDA1; LGMD2C; SCARMD2; gamma-SG
??[Similar Products]
NCBI Protein Information
gamma-sarcoglycan
UniProt Protein Name
Gamma-sarcoglycan
UniProt Synonym Protein Names
35 kDa dystrophin-associated glycoprotein; 35DAG
Protein Family
Gamma-sarcoglycan
UniProt Gene Name
SGCG??[Similar Products]
UniProt Synonym Gene Names
Gamma-SG; 35DAG??[Similar Products]
UniProt Entry Name
SGCG_HUMAN
NCBI Summary for SGCG
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
UniProt Comments for SGCG
SGCG: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterized by progressive muscle wasting from early childhood. Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Protein type: Dystrophin complex; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: cytoplasm; cytoskeleton; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma
Molecular Function: protein binding
Biological Process: cardiac muscle development; heart contraction; muscle cell development; muscle development
Disease: Muscular Dystrophy, Limb-girdle, Type 2c
Research Articles on SGCG
1. These results position archvillin as a mechanically sensitive component of the dystrophin complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus.
Precautions
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Disclaimer
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