Product Name
ACTA2, cDNA Clone
Popular Item
Full Product Name
ACTA2 cDNA Clone
Product Gene Name
ACTA2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtgtgaag aagaggacag cactgccttg gtgtgtgaca atggctctgg gctctgtaag gccggctttg ctggggacga tgctcccagg gctgttttcc catccattgt gggacgtccc agacatcagg gggtgatggt gggaatggga caaaaagaca gctacgtggg tgacgaagca cagagcaaaa gaggaatcct gaccctgaag tacccgatag aacatggcat catcaccaac tgggacgaca tggaaaagat ctggcaccac tctttctaca atgagcttcg tgttgcccct gaagagcatc ccaccctgct cacggaggca cccctgaacc ccaaggccaa ccgggagaaa atgactcaaa ttatgtttga gactttcaat gtcccagcca tgtatgtggc tatccaggcg gtgctgtctc tctatgcctc tggacgcaca actggcatcg tgctggactc tggagatggt gtcacccaca atgtccccat ctatgagggc tatgccttgc cccatgccat catgcgtctg gatctggctg gccgagatct cactgactac ctcatgaaga tcctgactga gcgtggctat tccttcgtta ctactgctga gcgtgagatt gtccgggaca tcaaggagaa actgtgttat gtagctctgg actttgaaaa tgagatggcc actgccgcat cctcatcctc ccttgagaag agttacgagt tgcctgatgg gcaagtgatc accatcggaa atgaacgttt ccgctgccca gagaccctgt tccagccatc cttcatcggg atggagtctg ctggcatcca tgaaaccacc tacaacagca tcatgaagtg tgatattgac atcaggaagg acctctatgc taacaatgtc ctatcagggg gcaccactat gtaccctggc attgccgacc gaatgcagaa ggagatcacg gccctagcac ccagcaccat gaagatcaag atcattgccc ctccggagcg caaatactct gtctggatcg gtggctccat cctggcctct ctgtccacct tccagcagat gtggatcagc aaacaggaat acgatgaagc cgggccttcc attgtccacc gcaaatgctt ctaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACTA2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACTA2. It may not necessarily be applicable to this product.
NCBI Accession #
BC017554
[Other Products]
UniProt Secondary Accession #
P03996; P04108; Q6FI19; B2R8A4[Other Products]
UniProt Related Accession #
P62736[Other Products]
Molecular Weight
42,009 Da
NCBI Official Full Name
Homo sapiens actin, alpha 2, smooth muscle, aorta, mRNA
NCBI Official Synonym Full Names
actin, alpha 2, smooth muscle, aorta
NCBI Official Symbol
ACTA2??[Similar Products]
NCBI Official Synonym Symbols
AAT6; ACTSA; MYMY5
??[Similar Products]
NCBI Protein Information
actin, aortic smooth muscle
UniProt Protein Name
Actin, aortic smooth muscle
UniProt Synonym Protein Names
Alpha-actin-2; Cell growth-inhibiting gene 46 protein
UniProt Gene Name
ACTA2??[Similar Products]
UniProt Synonym Gene Names
ACTSA; ACTVS??[Similar Products]
UniProt Entry Name
ACTA_HUMAN
NCBI Summary for ACTA2
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
UniProt Comments for ACTA2
ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.
Protein type: Motility/polarity/chemotaxis; Contractile; Cytoskeletal
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: cytoplasm; cytosol; extracellular space; filopodium; lamellipodium; protein complex
Molecular Function: protein kinase binding
Biological Process: muscle contraction; response to virus
Disease: Aortic Aneurysm, Familial Thoracic 6; Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome
Research Articles on ACTA2
1. alpha-SMA expression, and MLC phosphorylation, whereas butaprost inhibited TGF-beta2-induced CPCG contraction, actin polymerization, and MLC phosphorylation.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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