Product Name
GBA2, cDNA Clone
Full Product Name
GBA2 cDNA Clone
Product Gene Name
GBA2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggaccc aggatccagg gaacatggga accggcgtcc cagcctcgga gcagataagc tgtgccaaag aggatccaca agtttattgc cctgaagaga ctggcggcac caaggatgtg caggttacag actgtaagag tcccgaagac agccgacccc caaaagagac ggactgctgc aatccggagg actctgggca gctgatggtt tcctatgagg gtaaagctat gggctaccag gtgcctccct ttggctggcg catctgtctg gctcatgagt ttacagagaa gaggaaaccc tttcaagcta acaacgtctc cctaagcaac atgataaagc atataggcat gggcttgagg tacctgcagt ggtggtaccg gaagacccat gtggaaaaga agacaccttt catcgacatg atcaattctg tacccctaag acagatttat ggttgtccct tgggtggcat cgggggaggc actattaccc gtggctggag aggccagttc tgtcgttggc agcttaaccc tggaatgtat cagcaccgga cagtcatcgc tgaccaattc acagtgtgcc tgcgtcggga agggcagact gtgtaccagc aagtcctgtc cctggagcgc ccaagtgtcc tccgcagctg gaactggggc ctgtgtgggt actttgcttt ctaccatgcc ctctatcccc gagcctggac tgtctatcag cttcctggcc agaatgtcac cctcacctgc cgtcagatca cacccatctt gccccatgac taccaggaca gcagcctgcc tgtaggagtc tttgtgtggg atgtggaaaa tgaaggggac gaagctctag atgtgtccat catgttctcc atgcggaatg gactgggtgg tggagacgat gccccagggg gtttgtggaa tgagcccttc tgtctggagc gtagcgggga aactgtccgg gggctgctcc tgcatcatcc aacccttcca aacccctaca cgatggctgt ggctgcacga gtcacggcag ctaccacggt aacccacatc acagcctttg accctgacag cacggggcag caggtgtggc aggatctact tcaggatgga cagctggact ctcccactgg ccaaagcacc cctacgcaga aaggagtagg cattgctgga gctgtgtgtg tttccagcaa gttgcgacct cgaggccagt gccgcctgga gttttcactg gcttgggaca tgcccaggat catgtttgga gctaaaggcc aagtccacta caggcggtat acaaggttct ttggccagga tggagatgca gcacctgccc tcagccacta tgcactgtgc cgatacgcag agtgggaaga gaggatctca gcttggcaga gcccggtatt ggatgacaga tcactgcctg cctggtacaa atctgcgctg ttcaatgaac tatacttcct ggctgatgga ggcacagtgt ggctggaagt tcttgaggac tccctaccag aggagctggg cagaaacatg tgtcacctcc gccccaccct acgggactac ggtcgatttg gctaccttga gggccaggag taccgcatgt acaacacata tgatgtccac ttttatgctt cctttgccct catcatgctc tggcccaaac ttgagctcag cctacagtat gacatggctc tggccactct cagggaggac ctgacacggc gacggtacct gatgagtggg gtgatggcac ctgtgaaaag gaggaacgtc atcccccatg atattgggga cccagatgat gaaccatggc tccgcgtcaa tgcatattta atccatgata ctgctgattg gaaggacctg aacctgaagt ttgtgctgca ggtttatcgg gactattacc tcacgggtga tcaaaacttc ctgaaggaca tgtggcctgt gtgtctagct gtgatggaat ctgaaatgaa gtttgacaag gaccatgatg gactcattga aaatggaggc tatgcagacc agacctatga tggatgggtg accacaggcc ccagtgctta ctgtggaggg ctgtggctgg cagctgtggc tgtgatggtc cagatggctg ctctgtgtgg ggcacaggac atccaggata agttttcttc tatcctcagc cggggccaag aagcctatga gagactgctg tggaatggcc gctattacaa ctatgacagc agctctcggc ctcagtctcg tagtgttatg tctgaccagt gtgctggaca gtggttcctg aaggcctgtg gcctaggaga aggagacact gaggtgtttc ctacccaaca tgtggtccgt gctctccaaa ctatctttga gctgaacgtc caggcctttg caggaggggc catgggggct gtgaatggga tgcagcccca tggtgtccct gataaatcca gtgtgcagtc tgatgaagtc tgggtgggtg tggtctacgg gctggcagct accatgatcc aagagggcct gacttgggag ggcttccaga cagctgaagg ctgctaccgt accgtgtggg agcgcctggg tctggccttc cagaccccag aggcatactg ccagcagcga gtgttccgct cactggccta catgcggcca ctgagcatat gggccatgca gctagccctg caacagcagc agcacaaaaa ggcctcctgg ccaaaagtca aacagggcac aggactaagg acagggccta tgtttggacc aaaggaagcc atggcaaacc tgagcccaga gtga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of GBA2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GBA2. It may not necessarily be applicable to this product.
NCBI Accession #
BC011363
[Other Products]
UniProt Secondary Accession #
Q5TCV6; Q96A51; Q96LY1; Q96SJ2; Q9H2L8; D3DRP2[Other Products]
UniProt Related Accession #
Q9HCG7[Other Products]
Molecular Weight
72,111 Da
NCBI Official Full Name
Homo sapiens glucosidase, beta (bile acid) 2, mRNA
NCBI Official Synonym Full Names
glucosylceramidase beta 2
NCBI Official Symbol
GBA2??[Similar Products]
NCBI Official Synonym Symbols
AD035; SPG46; NLGase
??[Similar Products]
NCBI Protein Information
non-lysosomal glucosylceramidase
UniProt Protein Name
Non-lysosomal glucosylceramidase
UniProt Synonym Protein Names
Beta-glucocerebrosidase 2; Beta-glucosidase 2; Glucosylceramidase 2
UniProt Gene Name
GBA2??[Similar Products]
UniProt Synonym Gene Names
KIAA1605; NLGase; Beta-glucosidase 2??[Similar Products]
UniProt Entry Name
GBA2_HUMAN
NCBI Summary for GBA2
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008]
UniProt Comments for GBA2
GBA2: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo. Belongs to the non-lysosomal glucosylceramidase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.2.1.45; Hydrolase; Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: integral to membrane; plasma membrane; smooth endoplasmic reticulum
Molecular Function: beta-glucosidase activity; glucosylceramidase activity
Biological Process: bile acid metabolic process; central nervous system neuron development; glycoside catabolic process; glycosphingolipid metabolic process
Disease: Spastic Paraplegia 46, Autosomal Recessive
Research Articles on GBA2
1. Spastic paraplegia/cerebellar ataxia patients have a severe deficit in GBA2 activity, because the GBA2 mutants are intrinsically inactive and/or reduced in amount.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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