Human Non-lysosomal glucosylceramidase (GBA2) ELISA kit; AD035; DKFZp762K054; KIAA1605; MGC16895; bile acid beta-glucosidase; non-lysosomal glucosylceramidase; glucosidase; beta (bile acid) 2

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

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Small volumes of GBA2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9337162 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the glucosidase, beta (bile acid) 2 (GBA2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GBA2. The ELISA analytical biochemical technique of the MBS9337162 kit is based on GBA2 antibody-GBA2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GBA2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GBA2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GBA2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

104,649 Da

glucosidase, beta (bile acid) 2

non-lysosomal glucosylceramidase; NLGase; glucosylceramidase 2; beta-glucocerebrosidase 2

Non-lysosomal glucosylceramidase

KIAA1605; AD035; NLGase; Beta-glucosidase 2??[Similar Products]

GBA2_HUMAN

This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008]

GBA2: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo. Belongs to the non-lysosomal glucosylceramidase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.45; Endoplasmic reticulum; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; smooth endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: beta-glucosidase activity; glucosylceramidase activity

Biological Process: glucosylceramide catabolic process; sphingolipid metabolic process; glycoside catabolic process; bile acid metabolic process; glycosphingolipid metabolic process; central nervous system neuron development

Disease: Spastic Paraplegia 46, Autosomal Recessive

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