Gamma-sarcoglycan; Gamma-SG; 35 kDa dystrophin-associated glycoprotein; 35DAG; SGCG

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This SGCG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the Central region of human SGCG.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-SGCG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Crown Antibodies; Signal Transduction

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

IHC~~1:25
WB~~1:1000

Immunohistochemical analysis of paraffin-embedded H. heart section using SGCG Antibody (Center). MBS9207398 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

SGCG Antibody (Center) western blot analysis in MCF-7,MDA-MB231,MDA-MB453 cell line lysates (35ug/lane).This demonstrates the SGCG antibody detected the SGCG protein (arrow).

32379

sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)

gamma-sarcoglycan

Gamma-sarcoglycan

Gamma-SG; 35DAG??[Similar Products]

SGCG_HUMAN

This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]

SGCG: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterized by progressive muscle wasting from early childhood. Belongs to the sarcoglycan beta/delta/gamma/zeta family.

Protein type: Dystrophin complex; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: cytoskeleton; cytoplasm; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma

Molecular Function: protein binding

Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development

Disease: Muscular Dystrophy, Limb-girdle, Type 2c

Noguchi S., et al. Science 270:819-822(1995).
McNally E.M., et al. Am. J. Hum. Genet. 59:1040-1047(1996).
Dunham A., et al. Nature 428:522-528(2004).
Thompson T.G., et al. J. Cell Biol. 148:115-126(2000).
Piccolo F., et al. Hum. Mol. Genet. 5:2019-2022(1996).

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