Product Name
glucosidase, beta (bile acid) 2 (GBA2), Polyclonal Antibody
Full Product Name
Rabbit anti-human glucosidase, beta (bile acid) 2 polyclonal Antibody
Product Synonym Names
glucosidase; beta (bile acid) 2; GBA2; AD035; DKFZp762K054; KIAA1605; MGC16895
Product Gene Name
anti-GBA2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160381 / sc-160379
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GBA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GBA2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GBA2. It may not necessarily be applicable to this product.
NCBI Accession #
EAW58349.1
[Other Products]
UniProt Secondary Accession #
Q5TCV6; Q96A51; Q96LY1; Q96SJ2; Q9H2L8; D3DRP2[Other Products]
UniProt Related Accession #
Q9HCG7[Other Products]
Molecular Weight
72,111 Da[Similar Products]
NCBI Official Full Name
glucosidase, beta (bile acid) 2, isoform CRA_d
NCBI Official Synonym Full Names
glucosidase, beta (bile acid) 2
NCBI Official Symbol
GBA2??[Similar Products]
NCBI Official Synonym Symbols
AD035; SPG46
??[Similar Products]
NCBI Protein Information
non-lysosomal glucosylceramidase; NLGase; glucosylceramidase 2; beta-glucocerebrosidase 2
UniProt Protein Name
Non-lysosomal glucosylceramidase
UniProt Synonym Protein Names
Beta-glucocerebrosidase 2; Beta-glucosidase 2; Glucosylceramidase 2
UniProt Gene Name
GBA2??[Similar Products]
UniProt Synonym Gene Names
KIAA1605; NLGase; Beta-glucosidase 2??[Similar Products]
UniProt Entry Name
GBA2_HUMAN
NCBI Summary for GBA2
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism. [provided by RefSeq, Jul 2008]
UniProt Comments for GBA2
GBA2: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O- glucosides, however, the relevance of such activity is unclear in vivo. Belongs to the non-lysosomal glucosylceramidase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Hydrolase; Membrane protein, integral; EC 3.2.1.45
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; smooth endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: beta-glucosidase activity; glucosylceramidase activity
Biological Process: glucosylceramide catabolic process; sphingolipid metabolic process; glycoside catabolic process; bile acid metabolic process; glycosphingolipid metabolic process; central nervous system neuron development
Disease: Spastic Paraplegia 46, Autosomal Recessive
Research Articles on GBA2
1. The GBA2 gene shows a low mutation frequency in a general population of complicated hereditary spastic paraparesis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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