Mouse Nephrocystin-1 (NPHP1) ELISA kit; FLJ97602; JBTS4; NPH1; SLSN1; nephrocystin 1; nephrocystin-1; nephronophthisis 1 (juvenile)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NPHP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9331085 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the nephronophthisis 1 (juvenile) (NPHP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NPHP1. The ELISA analytical biochemical technique of the MBS9331085 kit is based on NPHP1 antibody-NPHP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NPHP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NPHP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

77,035 Da

nephronophthisis 1 (juvenile) homolog (human)

nephrocystin-1; nephrocystin 1

Nephrocystin-1

Nph1??[Similar Products]

NPHP1_MOUSE

NPHP1: Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis. Interacts with BCAR1, PTK2B/PYK2 and tensin. Interacts with INVS and NPHP3. Interacts with PACS1; the interaction is dependent on NPHP1 phosphorylation by CK2. Interatcs with KIF7. Interacts with AHI1 and TNK2. Interacts with NPHP4 in a complex containing NPHP1, NPHP4 and RPGRIP1L. Interacts with IQCB1; the interaction likely requires additional interactors. Widespread expression, with highest levels in pituitary gland, spinal cord, thyroid gland, testis, skeletal muscle, lymph node and trachea. Weakly expressed in heart, kidney and pancreas. Expressed in nasal epithelial cells. Belongs to the nephrocystin-1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Cellular Component: cytoskeleton; cell projection; tight junction; cytoplasm; intercellular junction; cell junction; photoreceptor connecting cilium; cilium

Molecular Function: protein binding

Biological Process: spermatid differentiation; cell projection organization and biogenesis; retina development in camera-type eye; spermatogenesis; cell differentiation

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