Product Name
Anthrax toxin receptor 2 (ANTXR2), Recombinant Protein
Full Product Name
Anthrax toxin receptor 2
Product Gene Name
ANTXR2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
34-489aa; full length protein
Sequence
QEQPSCRRAF DLYFVLDKSG SVANNWIEIY NFVQQLAERF VSPEMRLSFI VFSSQATIIL PLTGDRGKIS KGLEDLKRVS PVGETYIHEG LKLANEQIQK AGGLKTSSII IALTDGKLDG LVPSYAEKEA KISRSLGASV YCVGVLDFEQ AQLERIADSK EQVFPVKGGF QALKGIINSI LAQSCTEILE LQPSSVCVGE EFQIVLSGRG FMLGSRNGSV LCTYTVNETY TTSVKPVSVQ LNSMLCPAPI LNKAGETLDV SVSFNGGKSV ISGSLIVTAT ECSNGIAAII VILVLLLLLG IGLMWWFWPL CCKVVIKDPP PPPAPAPKEE EEEPLPTKKW PTVDASYYGG RGVGGIKRME VRWGDKGSTE EGARLEKAKN AVVKIPEETE EPIRPRPPRP KPTHQPPQTK WYTPIKGRLD ALWALLRRQY DRVSLMRPQE GDEVCIWECI EKELTA
3D Structure
ModBase 3D Structure for P58335
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ANTXR2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ANTXR2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for ANTXR2 recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for ANTXR2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001139266.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001145794.1
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UniProt Primary Accession #
P58335
[Other Products]
UniProt Secondary Accession #
Q4W5H6; Q59E98; Q5JPE9; Q86UI1; Q8N4J8; Q8NB13; Q96NC7[Other Products]
UniProt Related Accession #
P58335[Other Products]
Molecular Weight
53,493 Da
NCBI Official Full Name
anthrax toxin receptor 2 isoform 2
NCBI Official Synonym Full Names
anthrax toxin receptor 2
NCBI Official Symbol
ANTXR2??[Similar Products]
NCBI Official Synonym Symbols
HFS; ISH; JHF; CMG2; CMG-2
??[Similar Products]
NCBI Protein Information
anthrax toxin receptor 2
UniProt Protein Name
Anthrax toxin receptor 2
UniProt Synonym Protein Names
Capillary morphogenesis gene 2 protein; CMG-2
Protein Family
Anthrax toxin receptor
UniProt Gene Name
ANTXR2??[Similar Products]
UniProt Synonym Gene Names
CMG2; CMG-2??[Similar Products]
UniProt Entry Name
ANTR2_HUMAN
NCBI Summary for ANTXR2
This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for ANTXR2
ANTXR2: Necessary for cellular interactions with laminin and the extracellular matrix. Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH). This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures. Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF). JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q21.21
Cellular Component: endosome membrane; plasma membrane
Molecular Function: protein binding
Disease: Hyaline Fibromatosis Syndrome
Research Articles on ANTXR2
1. The disulfide bond Cys255-Cys279 in the immunoglobulin-like domain of ANTXR2 is required for membrane insertion of anthrax protective antigen pore.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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