Full Product Name
Anti-Ctdp1 (RNA polymerase II subunit A C-terminal domain phosphatase) Antibody
Product Gene Name
anti-CTDP1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
Purified by antigen-specific affinity chromatography.
Concentration
1ug/ul (lot specific)
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse Ctdp1 (RNA polymerase II subunit A C-terminal domain phosphatase)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-CTDP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CTDP1 antibody
Ctdp1 (RNA polymerase II subunit A C-terminal domain phosphatase) processively dephosphorylates Ser-2 and Ser-5 of the heptad repeats YSPTSPS in the carboxyl-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Ctdp1 interacts with GTF2F1. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1.
Applications Tested/Suitable for anti-CTDP1 antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CTDP1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH52576.1
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UniProt Secondary Accession #
Q7Z644; Q96BZ1; Q9Y6F5; A8MY97[Other Products]
UniProt Related Accession #
Q9Y5B0[Other Products]
Molecular Weight
93,485 Da
NCBI Official Full Name
CTDP1 protein, partial
NCBI Official Synonym Full Names
CTD phosphatase subunit 1
NCBI Official Symbol
CTDP1??[Similar Products]
NCBI Official Synonym Symbols
FCP1; CCFDN
??[Similar Products]
NCBI Protein Information
RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Protein Name
RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Synonym Protein Names
TFIIF-associating CTD phosphatase
UniProt Gene Name
CTDP1??[Similar Products]
UniProt Synonym Gene Names
FCP1??[Similar Products]
NCBI Summary for CTDP1
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for CTDP1
CTDP1: a phospho-serine/threonine protein phosphatase which interacts with the carboxy-terminus of transcription initiation factor TFIIF-alpha, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. Its phosphorylation increases binding to TFIIF-alpha, affecting transcription elongation. Alternative splicing results in two different isoforms.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: actin cytoskeleton; centrosome; DNA-directed RNA polymerase II, holoenzyme; midbody; nucleoplasm; spindle; spindle midzone; spindle pole
Molecular Function: CTD phosphatase activity; phosphoprotein phosphatase activity; protein binding
Biological Process: exit from mitosis; positive regulation of viral transcription; protein amino acid dephosphorylation; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Product References and Citations for anti-CTDP1 antibody
Yamamoto, K., et al, Mol. Cell. Biol. 24 (14), 6338-6349 (2004)
Research Articles on CTDP1
1. results demonstrated that CTDP1 was upregulated in human lung cancer tissues. In addition, it implied that CTDP1 played an important role in cell proliferation and may be a useful therapeutic target in human lung cancer.
Precautions
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Disclaimer
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