Full Product Name
PRIO Polyclonal Antibody
Product Synonym Names
Major prion protein; PrP; ASCR; PrP27-30; PrP33-35C; CD antigen CD230; PRNP; PRIP; PRP
Product Gene Name
anti-PRIO antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P04156
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-PRIO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PRIO antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PRIO antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for PRIO. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000302.1
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NCBI GenBank Nucleotide #
NM_000311.4
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UniProt Primary Accession #
P04156
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UniProt Secondary Accession #
O60489; P78446; Q15216; Q15221; Q27H91; Q5QPB4; Q8TBG0; Q96E70; Q9UP19[Other Products]
UniProt Related Accession #
P04156; F7VJQ1[Other Products]
NCBI Official Full Name
major prion protein Prp preproprotein
NCBI Official Synonym Full Names
prion protein
NCBI Official Symbol
PRNP??[Similar Products]
NCBI Official Synonym Symbols
CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C
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NCBI Protein Information
major prion protein; alternative prion protein
UniProt Protein Name
Major prion protein
UniProt Synonym Protein Names
ASCR; PrP27-30; PrP33-35C; CD_antigen: CD230
Protein Family
Prion-like protein doppel
UniProt Gene Name
PRNP??[Similar Products]
UniProt Synonym Gene Names
ALTPRP; PRIP; PRP; PrP??[Similar Products]
NCBI Summary for PRIO
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Comments for PRIO
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains ().
Research Articles on PRIO
1. Those data indicate that the overexpression of PLK3-mediated degradation of abnormal PrP is largely dependent on chaperone-mediated autophagy pathway.
Precautions
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Disclaimer
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