Product Name
CTDP1, Blocking Peptide
Full Product Name
CTDP1 Antibody (N-term) Blocking Peptide
Product Synonym Names
RNA polymerase II subunit A C-terminal domain phosphatase; TFIIF-associating CTD phosphatase; CTDP1; FCP1
Product Gene Name
CTDP1 blocking peptide
[Similar Products]
Product Synonym Gene Name
FCP1[Similar Products]
Antibody/Peptide Pairs
CTDP1 peptide (MBS9226214) is used for blocking the activity of CTDP1 antibody (MBS9210416)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y5B0
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CTDP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note: Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively
Tissue Location
Ubiquitously expressed.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of CTDP1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CTDP1 blocking peptide
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.
NCBI/Uniprot data below describe general gene information for CTDP1. It may not necessarily be applicable to this product.
NCBI Accession #
Q9Y5B0.3
[Other Products]
UniProt Primary Accession #
Q9Y5B0
[Other Products]
UniProt Secondary Accession #
Q7Z644; Q96BZ1; Q9Y6F5; A8MY97[Other Products]
UniProt Related Accession #
Q9Y5B0[Other Products]
Molecular Weight
93,485 Da
NCBI Official Full Name
RNA polymerase II subunit A C-terminal domain phosphatase
NCBI Official Synonym Full Names
CTD phosphatase subunit 1
NCBI Official Symbol
CTDP1??[Similar Products]
NCBI Official Synonym Symbols
FCP1; CCFDN
??[Similar Products]
NCBI Protein Information
RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Protein Name
RNA polymerase II subunit A C-terminal domain phosphatase
UniProt Synonym Protein Names
TFIIF-associating CTD phosphatase
UniProt Gene Name
CTDP1??[Similar Products]
UniProt Synonym Gene Names
FCP1??[Similar Products]
UniProt Entry Name
CTDP1_HUMAN
NCBI Summary for CTDP1
This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for CTDP1
CTDP1: a phospho-serine/threonine protein phosphatase which interacts with the carboxy-terminus of transcription initiation factor TFIIF-alpha, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. Its phosphorylation increases binding to TFIIF-alpha, affecting transcription elongation. Alternative splicing results in two different isoforms.
Protein type: Transcription initiation complex; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q23
Cellular Component: actin cytoskeleton; centrosome; DNA-directed RNA polymerase II, holoenzyme; midbody; nucleoplasm; spindle; spindle midzone; spindle pole
Molecular Function: CTD phosphatase activity; phosphoprotein phosphatase activity; protein binding
Biological Process: exit from mitosis; positive regulation of viral transcription; protein amino acid dephosphorylation; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter
Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Research Articles on CTDP1
1. Data propose that Fcp1 has a crucial role in the liaison between dephosphorylation and ubiquitination that drives mitosis exit.
Precautions
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Disclaimer
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