Full Product Name
Mouse C5 Polyclonal Antibody
Product Synonym Names
Hc; Hemolytic complement
Product Gene Name
anti-C5 antibody
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Matching Pairs
Antibody: C5 (MBS2899025)
Antigen: Complement C5 (MBS2889413)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01031
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human C5 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-C5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-C5 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for C5. It may not necessarily be applicable to this product.
NCBI Accession #
EAW87480.1
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UniProt Primary Accession #
P01031
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UniProt Related Accession #
P01031[Other Products]
NCBI Official Full Name
complement component 5
NCBI Official Synonym Full Names
complement C5
NCBI Official Symbol
C5??[Similar Products]
NCBI Official Synonym Symbols
C5D; C5a; C5b; ECLZB; CPAMD4
??[Similar Products]
NCBI Protein Information
complement C5
UniProt Protein Name
Complement C5
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Protein Family
C5a peptidase
UniProt Gene Name
C5??[Similar Products]
UniProt Synonym Gene Names
CPAMD4??[Similar Products]
UniProt Entry Name
CO5_HUMAN
NCBI Summary for C5
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
UniProt Comments for C5
C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 9q33-q34
Cellular Component: membrane attack complex; extracellular space; extracellular region
Molecular Function: protein binding; chemokine activity; endopeptidase inhibitor activity; receptor binding; C5a anaphylatoxin chemotactic receptor binding
Biological Process: activation of MAPK activity; positive regulation of chemotaxis; in utero embryonic development; cytolysis; complement activation, alternative pathway; chemotaxis; glucose homeostasis; leukocyte migration during inflammatory response; complement activation; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of complement activation; response to stress; innate immune response; negative regulation of dopamine secretion; inflammatory response; complement activation, classical pathway
Disease: Complement Component 5 Deficiency; Eculizumab, Poor Response To
Research Articles on C5
1. In addition, an in vitro experiment revealed C5aR deficiency promoted the development of regulatory T cells whereas C5a activation abolished the differentiation of regulatory T cells.
Precautions
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